Postdoctoral Fellow: Fan Cheng, Ph.D.
Identification of cellular pathways activated during KSHV acute infection and those that are essential for KSHV infection with the ultimate goal to better understand virus-host interactions and identify potential anti-viral therapeutic targets.
1. Role of host innate immunity in KSHV-induced inflammation, angiogenesis, cellular transformation and tumorigenesis.
2. High content screening for novel inhibitors targeting KSHV-induced oncogenic addiction.
My main interest is to understand the molecular mechanism of tumorigenesis. Currently, I am investigating the genome-wide reprogramming of cellular epigenetic marks by oncogenic virus, KSHV. I intend to identify the transcriptional factors and epigenetic drivers that mediate KSHV-induced cellular transformation tumorigenesis. Outside the lab, I enjoy the outdoor activities in the sunshine of LA.
I obtained my B.S. in Biomedical Science, and M.S. and Ph.D. in Pathology from Sao Paulo State University (UNESP), Brazil. I have been studying KSHV since I was an undergraduate. During my Ph.D. training, I had the opportunity to be part of Drs. Chang & Moore’s Laboratory at the University of Pittsburgh, PA (2005-2006). After completion of Ph.D., I continued to work as a Postdoctoral Follow under the guidance of Dr. Deilson Elgui de Oliveira in Sao Paulo State University. I joined Dr. Gao’s laboratory in 2012.
My current focus is on KSHV major latent protein LANA-1, and cellular proteins that are involved in KSHV-induced metabolic reprogramming and cellular transformation.
1. Crispr-Cas9 screening of cellular genes essential for KSHV-induced cellular transformation.
2. Roles and mechanisms of action of KSHV miRNAs in angiogenesis.
3. Roles of sirtuins in diffuse large B-cell lymphoma.
© 2014, Gao Lab