Comai Lab

Publications

  1. Downregulation of the Werner syndrome protein induces a metabolic shift that compromises redox homeostasis and limits proliferation of cancer cells. Li B, Iglesias-Pedraz JM, Chen LY, Yin F, Cadenas E, Reddy S, Comai L. Aging Cell. 2014 Apr;13(2):367-78. PMID: 24757718
  2. RNA splicing is responsive to MBNL1 dose. Jog SP, Paul S, Dansithong W, Tring S, Comai L, Reddy S. PLoS One. 2012;7(11):e48825. PMID:23166594
  3. A filtering strategy identifies FOXQ1 as a potential effector of lamin A dysfunction. Candelario J, Chen LY, Marjoram P, Reddy S, Comai L. Aging (Albany NY). 2012 Aug;4(8):567-77. PMID:22948034
  4. Expanded CUG repeats Dysregulate RNA splicing by altering the stoichiometry of the muscleblind 1 complex. Paul S, Dansithong W, Jog SP, Holt I, Mittal S, Brook JD, Morris GE, Comai L, Reddy S. J Biol Chem. 2011 Nov 4;286(44):38427-38. PMID:21900255
  5. Lamin A, farnesylation and aging. Reddy S, Comai L. Exp Cell Res. 2012 Jan 1;318(1):1-7. PMID:21871450
  6. RNA steady-state defects in myotonic dystrophy are linked to nuclear exclusion of SHARP. Dansithong W, Jog SP, Paul S, Mohammadzadeh R, Tring S, Kwok Y, Fry RC, Marjoram P, Comai L, Reddy S. EMBO Rep. 2011 Jul 1;12(7):735-42. PMID:21637295
  7. Cell cycle-regulated association between the Werner syndrome protein and its molecular partners. Jog SP, Reddy S, Comai L. Cell Cycle. 2011 Jun 15;10(12):2038-40. PMID: 21558813
  8. Depletion of Ku70/80 reduces the levels of extrachromosomal telomeric circles and inhibits proliferation of ALT cells. Li B, Reddy S, Comai L. Aging (Albany NY). 2011 Apr;3(4):395-406. PMID:21512205
  9. Hepatitis C virus inhibits DNA damage repair through reactive oxygen and nitrogen species and by interfering with the ATM-NBS1/Mre11/Rad50 DNA repair pathway in monocytes and hepatocytes. Machida K, McNamara G, Cheng KT, Huang J, Wang CH, Comai L, Ou JH, Lai MM. J Immunol. 2010 Dec 1;185(11):6985-98. doi: 10.4049/jimmunol.1000618. Epub 2010 Oct 25. PMID: 20974981
  10. Accumulation of distinct prelamin A variants in human diploid fibroblasts differentially affects cell homeostasis. Candelario J, Borrego S, Reddy S, Comai L. Exp Cell Res. 2011 Feb 1;317(3):319-29. doi: 10.1016/j.yexcr.2010.10.014. Epub 2010 Oct 23. PMID: 20974128
  11. Processing of human telomeres by the Werner syndrome protein. Reddy S, Li B, Comai L. Cell Cycle. 2010 Aug 15;9(16):3137-8. PMID:20814240
  12. Sequence-specific processing of telomeric 3′ overhangs by the Werner syndrome protein exonuclease activity. Li B, Reddy S, Comai L. Aging (Albany NY). 2009 Mar 17;1(3):289-302. PMID: 20157518
  13. Altered nuclear functions in progeroid syndromes: a paradigm for aging research. Li B, Jog S, Candelario J, Reddy S, Comai L. ScientificWorldJournal. 2009 Dec 16;9:1449-62. PMID: 20024518
  14. Regulation of lymphoid tyrosine phosphatase activity: inhibition of the catalytic domain by the proximal interdomain. Liu Y, Stanford SM, Jog SP, Fiorillo E, Orrú V, Comai L, Bottini N. Biochemistry. 2009 Aug 11;48(31):7525-32. doi: 10.1021/bi900332f. PMID:19586056
  15. Cytoplasmic CUG RNA foci are insufficient to elicit key DM1 features. Dansithong W, Wolf CM, Sarkar P, Paul S, Chiang A, Holt I, Morris GE, Branco D, Sherwood MC,Comai L, Berul CI, Reddy S. PLoS One. 2008;3(12):e3968. PMID: 19092997
  16. Perturbation of wild-type lamin A metabolism results in a progeroid phenotype. Candelario J, Sudhakar S, Navarro S, Reddy S, Comai L. Aging Cell. 2008 Jun;7(3):355-67. PMID: 18363904
  17. WRN controls formation of extrachromosomal telomeric circles and is required for TRF2DeltaB-mediated telomere shortening. Li B, Jog SP, Reddy S, Comai L. Mol Cell Biol. 2008 Mar;28(6):1892-904.PMID:18212065
  18. Longevity mutation in SCH9 prevents recombination errors and premature genomic instability in a Werner/Bloom model system. Madia F, Gattazzo C, Wei M, Fabrizio P, Burhans WC, Weinberger M, Galbani A, Smith JR, Nguyen C, Huey S, Comai L, Longo VD. J Cell Biol. 2008 Jan 14;180(1):67-81. PMID:18195102
  19. Mass spectrometric identification of phosphorylation sites of rRNA transcription factor upstream binding factor. Lin CH, Platt MD, Ficarro SB, Hoofnagle MH, Shabanowitz J, Comai L, Hunt DF, Owens GK. Am J Physiol Cell Physiol. 2007 May;292(5):C1617-24. PMID:17182730
  20. CK2-mediated stimulation of Pol I transcription by stabilization of UBF-SL1 interaction. Lin CY, Navarro S, Reddy S, Comai L. Nucleic Acids Res. 2006;34(17):4752-66. Epub 2006 Sep 13. PMID:16971462
  21. Interaction of muscleblind, CUG-BP1 and hnRNP H proteins in DM1-associated aberrant IR splicing. Paul S, Dansithong W, Kim D, Rossi J, Webster NJ, Comai L, Reddy S. EMBO J. 2006 Sep 20;25(18):4271-83. PMID:16946708
  22. Direct regulation of rRNA transcription by fibroblast growth factor 2. Sheng Z, Liang Y, Lin CY, Comai L, Chirico WJ. Mol Cell Biol. 2005 Nov;25(21):9419-26. PMID: 16227592
  23. PTEN represses RNA Polymerase I transcription by disrupting the SL1 complex. Zhang C, Comai L, Johnson DL. Mol Cell Biol. 2005 Aug;25(16):6899-911. PMID: 16055704
  24. Modifications of both selectivity factor and upstream binding factor contribute to poliovirus-mediated inhibition of RNA polymerase I transcription. Banerjee R, Weidman MK, Navarro S, Comai L, Dasgupta A. J Gen Virol. 2005 Aug;86(Pt 8):2315-22. PMID: 16033979
  25. MBNL1 is the primary determinant of focus formation and aberrant insulin receptor splicing in DM1. Dansithong W, Paul S, Comai L, Reddy S. J Biol Chem. 2005 Feb 18;280(7):5773-80. PMID:15546872
  26. Mechanism of RNA polymerase I transcription. Comai L. Adv Protein Chem. 2004;67:123-55. PMID: 14969726
  27. Identification and biochemical characterization of a Werner’s syndrome protein complex with Ku70/80 and poly(ADP-ribose) polymerase-1. Li B, Navarro S, Kasahara N, Comai L. J Biol Chem. 2004 Apr 2;279(14):13659-67. PMID:14734561
  28. Coimmunoprecipitation assay for the detection of kinase-substrate interactions. Comai L. Methods Mol Biol. 2003;218:277-84. PMID:12616727
  29. The cell cycle regulatory factor TAF1 stimulates ribosomal DNA transcription by binding to the activator UBF. Lin CY, Tuan J, Scalia P, Bui T, Comai L. Curr Biol. 2002 Dec 23;12(24):2142-6. PMID: 12498690
  30. Displacement of DNA-PKcs from DNA ends by the Werner syndrome protein. Li B, Comai L. Nucleic Acids Res. 2002 Sep 1;30(17):3653-61. PMID: 12202749
  31. Regulation of the Akt/Glycogen synthase kinase-3 axis by insulin-like growth factor-II via activation of the human insulin receptor isoform-A. Scalia P, Heart E, Comai L, Vigneri R, Sung CK. J Cell Biochem. 2001;82(4):610-8. PMID: 11500939
  32. Requirements for the nucleolytic processing of DNA ends by the Werner syndrome protein-Ku70/80 complex. Li B, Comai L. J Biol Chem. 2001 Mar 30;276(13):9896-902. PMID: 11152456
  33. Repression of RNA polymerase I transcription by the tumor suppressor p53. Zhai W, Comai L. Mol Cell Biol. 2000 Aug;20(16):5930-8. PMID: 10913176
  34. Functional interaction between Ku and the werner syndrome protein in DNA end processing. Li B, Comai L. J Biol Chem. 2000 Sep 15;275(37):28349-52. PMID: 10880505
  35. Inhibition of RNA polymerase I transcription in differentiated myeloid leukemia cells by inactivation of selectivity factor 1. Comai L, Song Y, Tan C, Bui T. Cell Growth Differ. 2000 Jan;11(1):63-70. PMID:10672904
  36. The nucleolus: a paradigm for cell proliferation and aging. Comai L. Braz J Med Biol Res. 1999 Dec;32(12):1473-8. PMID:10585627
  37. Recruitment of TATA-binding protein-TAFI complex SL1 to the human ribosomal DNA promoter is mediated by the carboxy-terminal activation domain of upstream binding factor (UBF) and is regulated by UBF phosphorylation. Tuan JC, Zhai W, Comai L. Mol Cell Biol. 1999 Apr;19(4):2872-9. PMID: 10082553
  38. A kinase activity associated with simian virus 40 large T antigen phosphorylates upstream binding factor (UBF) and promotes formation of a stable initiation complex between UBF and SL1. Zhai W, Comai L. Mol Cell Biol. 1999 Apr;19(4):2791-802. PMID: 10082545
  39. Heterogeneous nuclear ribonucleoprotein A1 binds to the transcription-regulatory region of mouse hepatitis virus RNA. Li HP, Zhang X, Duncan R, Comai L, Lai MM. Proc Natl Acad Sci U S A. 1997 Sep 2;94(18):9544-9. PMID: 9275159
  40. SV40 large T antigen binds to the TBP-TAF(I) complex SL1 and coactivates ribosomal RNA transcription. Zhai W, Tuan JA, Comai L. Genes Dev. 1997 Jun 15;11(12):1605-17. PMID:9203586
  41. The rDNA transcription machinery is assembled during mitosis in active NORs and absent in inactive NORs. Roussel P, André C, Comai L, Hernandez-Verdun D. J Cell Biol. 1996 Apr;133(2):235-46. PMID: 8609158
  42. Assembly of transcriptionally active RNA polymerase I initiation factor SL1 from recombinant subunits. Zomerdijk JC, Beckmann H, Comai L, Tjian R. Science. 1994 Dec 23;266(5193):2015-8. PMID: 7801130
  43. Reconstitution of transcription factor SL1: exclusive binding of TBP by SL1 or TFIID subunits. Comai L, Zomerdijk JC, Beckmann H, Zhou S, Admon A, Tjian R. Science. 1994 Dec 23;266(5193):1966-72. PMID:7801123
  44. Isocitrate lyase and malate synthase genes from Brassica napus L. are active in pollen. Zhang JZ, Laudencia-Chingcuanco DL, Comai L, Li M, Harada JJ. Plant Physiol. 1994 Mar;104(3):857-64. No abstract available. PMID:8165259
  45. The TATA-binding protein and associated factors are integral components of the RNA polymerase I transcription factor, SL1. Comai L, Tanese N, Tjian R. Cell. 1992 Mar 6;68(5):965-76.PMID:1547496
  46. Transcriptional activities in dry seed nuclei indicate the timing of the transition from embryogeny to germination. Comai L, Harada JJ. Proc Natl Acad Sci U S A. 1990 Apr;87(7):2671-4. PMID: 2320581
  47. Coordinate expression of transcriptionally regulated isocitrate lyase and malate synthase genes in Brassica napus L. Comai L, Dietrich RA, Maslyar DJ, Baden CS, Harada JJ. Plant Cell. 1989 Mar;1(3):293-300. PMID: 2535504
  48. Deduced sequence of a malate synthase polypeptide encoded by a subclass of the gene family. Comai L, Baden CS, Harada JJ. J Biol Chem. 1989 Feb 15;264(5):2778-82. PMID: 2914930