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The fundamental goal of Dr. Comai’s research program is to advance our knowledge of the molecular mechanisms underlying the development of diseases characterized by a broad spectrum of age-related pathologies. Currently, the lab is focused on understanding the cellular processes leading to the development of genetic diseases including Werner syndrome (WS), a premature aging disease and Myotonic Dystrophy type 1 (DM1), a form of muscular dystrophy caused by trinucleotide repeats expansion. The lab utilizes biochemical, genetic and molecular biology approaches to dissect the molecular pathways and mechanisms responsible for these diseases with the goal to translate basic science findings into pharmacological interventions.