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Dr. Comai’s research program investigates the molecular basis of human aging. The current focus is on the identification of the cellular processes responsible for the development of Werner syndrome (WS) and Hutchinson-Gilford Progeria syndrome (HGPS), two genetic diseases of accelerated aging. The lab utilizes biochemical, genetic and molecular biology approaches to dissect the molecular pathways and mechanisms responsible for these diseases with the goal to translate basic science findings into pharmacological interventions to cure premature aging as well as treat unhealthy aging in the general population.