Publications
30.Lee JJ, Lee SK, Song N, Nathan TO, Swarts BM, Eum SY, Ehrt S, Cho SN, Eoh H. Transient drug-tolerance and permanent drug-resistance rely on the trehalose-catalytic shift in Mycobacterium tuberculosis. Nat Commun. 2019 Jul 2;10(1):2928.
29. Dutta NK, Klinkenberg LG, Vazquez MJ, Segura-Carro D, Colmenarejo G, Ramon F, Rodriguez-Miquel B, Mata-Cantero L, Porras-De Francisco E, Chuang YM, Rubin H, Lee JJ, Eoh H, Bader JS, Perez-Herran E, Mendoza-Losana A, Karakousis PC. Inhibiting the stringent response blocks Mycobacterium tuberculosisentry into quiescence and reduces persistence. Sci Adv. 2019 Mar 20;5(3):eaav2104.
28. Eoh H ǂ, Jung JU. Bacterial Protein Reshapes Host Defense toward Antiviral Responses. Mol Cell. 2018 Aug 16;71(4):483-484. doi: 10.1016/j.molcel.2018.08.006.ǂ Corresponding Author.
27. Kim PM, Lee JJ, Choi D, Eoh H ǂ, Hong YK. Endothelial lineage-specific interaction of Mycobacterium tuberculosiswith the blood and lymphatic systems. Tuberculosis (Edinb). 2018 Jul;111:1-7. doi: 10.1016/j.tube.2018.04.009. Epub 2018 May 4. Review.ǂ Corresponding Author.
26. Lee JJ, Lim J, Gao S, Lawson CP, Odell M, Raheem S, Woo J, Kang SH, Kang SS, Jeon BY, Eoh H. Glutamate mediated metabolic neutralization mitigates propionate toxicity in intracellular Mycobacterium tuberculosis. Sci Rep. 2018 May 31;8(1):8506.
25. Seo GJ, Kim C, Shin WJ, Sklan EH, Eoh H, Jung JU. TRIM56-mediated monoubiquitination of cGAS for cytosolic DNA sensing. Nat Commun. 2018 Feb 9;9(1):613.
24. Zhu Y, Li T, Ramos da Silva S, Lee JJ, Lu C, Eoh H, Jung JU, Gao SJ. A Critical Role of Glutamine and Asparagine γ-Nitrogen in Nucleotide Biosynthesis in Cancer Cells Hijacked by an Oncogenic Virus. MBio. 2017 Aug 15;8(4). pii: e01179-17.
23. Wu WL, Grotefend CR, Tsai MT, Wang YL, Radic V, Eoh H, Huang IC. Δ20 IFITM2 differentially restricts X4 and R5 HIV-1. Proc Natl Acad Sci U S A. 2017 Jul 3;114(27):7112-7117.
22. Eoh H, Wang Z, Layre E, Rath P, Morris R, Branch Moody D, Rhee KY. Metabolic anticipation in Mycobacterium tuberculosis. Nat Microbiol. 2017 May 22;2:17084.
21. Puckett S, Trujillo C, Wang Z, Eoh H, Ioerger TR, Krieger I, Sacchettini J, Schnappinger D, Rhee KY, Ehrt S. Glyoxylate detoxification is an essential function of malate synthase required for carbon assimilation in Mycobacterium tuberculosis. Proc Natl Acad Sci U S A. 2017 Mar 14;114(11):E2225-E2232.
20. Evans JC, Trujillo C, Wang Z, Eoh H, Ehrt S, Schnappinger D, Boshoff HI, Rhee KY, Barry CE 3rd, Mizrahi V.Validation of CoaBC as a Bactericidal Target in the Coenzyme A Pathway of Mycobacterium tuberculosis. ACS Infect Dis. 2016 Oct 5.
19. Saini V, Cumming BM, Guidry L, Lamprecht DA, Adamson JH, Reddy VP, Chinta KC, Mazorodze JH, Glasgow JN, Richard-Greenblatt M, Gomez-Velasco A, Bach H, Av-Gay Y, Eoh H, Rhee K, Steyn AJ. Ergothioneine Maintains Redox and Bioenergetic Homeostasis Essential for Drug Susceptibility and Virulence of Mycobacterium tuberculosis.Cell Rep. 2016 Jan 26;14(3):572-85.
18. Katragkou A, Alexander EL, Eoh H, Raheem SK, Roilides E, Walsh TJ. Effects of fluconazole on the metabolomic profile of Candida albicans.J Antimicrob Chemother. 2016 Mar;71(3):635-40.
17. Ganapathy U, Marrero J, Calhoun S, Eoh H, de Carvalho LP, Rhee K, Ehrt S. 2015. Two enzymes with redundant fructose bisphosphatase activity sustain gluconeogenesis and virulence in Mycobacterium tuberculosis. Nature Commun. Aug. 10;6:7912.
16. Eoh H ǂ 2014. Metabolomics: a window into the adaptive physiology of Mycobacterium tuberculosis. Tuberculosis (Edinb). Dec;94(6):538-43. Review.ǂ Corresponding Author.
15. Puckett S, Trujillo C, Eoh H, Marrero J, Spencer J, Jackson M, Schnappinger D, Rhee K, Ehrt S. 2014. Inactivation of fructose-1,6-bisphosphate aldolase prevents optimal co-catabolism of glycolytic and gluconeogenic carbon substrates in Mycobacterium tuberculosis. PLoS Pathog. 2014 May 22;10(5):e1004144.
14.Eoh H, Rhee KY. 2014. Methylcitrate cycle defines the bactericidal essentiality of isocitrate lyase for survival of Mycobacterium tuberculosison fatty acids. Proc Natl Acad Sci U S A. 2014 Apr 1;111(13):4976-81.
13. Eoh H, Rhee KY. 2014. Allostery and compartmentalization: old but not forgotten. Curr Opin Microbiol. 2014 Apr;18:23-9. Review.
12. Eoh H, Rhee KY. 2013. Multifunctional essentiality of succinate metabolism in adaptation to hypoxia in Mycobacterium tuberculosis. Proc Natl Acad Sci U S A. Apr 16;110(16):6554-9.
11. Jeon BY, Eoh H, Ha SJ, Bang H, Kim SC, Sung YC, Cho SN. 2011. Co-immunization of plasmid DNA encoding IL-12 and IL-18 with Bacillus Calmette-Guérin vaccine against progressive tuberculosis. Yonsei Med J. 2011 Nov;52(6):1008-15.
10. Woong Park S, Klotzsche M, Wilson DJ, Boshoff HI, Eoh H, Manjunatha U, Blumenthal A, Rhee K, Barry CE 3rd, Aldrich CC, Ehrt S, Schnappinger D. 2011. Evaluating the sensitivity of Mycobacterium tuberculosisto biotin deprivation using regulated gene expression. PLoS Pathog. Sep;7(9):e1002264.
9. Jani C *, Eoh H *, Lee JJ *, Hamasha K, Sahana MB, Han JS, Nyayapathy S, Lee JY, Suh JW, Lee SH, Rehse SJ, Crick DC, Kang CM. 2010. Regulation of polar peptidoglycan biosynthesis by Wag31 phosphorylation in mycobacteria. BMC Microbiol. Dec 29;10:327. * Equal contribution.
8. Eoh H, Jeon BY, Kim Z, Kim SC, Cho SN. 2010. Expression and validation of D-erythrulose 1-phosphate dehydrogenase from Brucella abortus: a diagnostic reagent for bovine brucellosis. J Vet Diagn Invest. Jul;22(4):524-30.
7. Narayanasamy P *, Eoh H *, Brennan PJ, Crick DC. 2010. Synthesis of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate and kinetic studies of Mycobacterium tuberculosis IspF. Chem Biol. Feb 26;17(2):117-22. *Equal contribution.
6. Eoh H *, Narayanasamy P *, Brown AC, Parish T, Brennan PJ, Crick DC. 2009. Expression and characterization of soluble 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase from bacterial pathogens. Chem Biol. Dec 24;16(12):1230-9. * Equal contribution.
5. Eoh H ǂ, Brennan PJ, Crick DC ǂ. 2009. The Mycobacterium tuberculosisMEP (2C-methyl-d-erythritol 4-phosphate) pathway as a new drug target. Tuberculosis (Edinb). Jan;89(1):1-11. ǂ Corresponding authors.
4. Narayanasamy P, Eoh H, Crick DC. 2008. Chemoenzymatic synthesis of 4-diphosphocytidyl-2-C-methyl-D-erythritol: A substrate for IspE. Tetrahedron Lett. Jul 21;49(29-30):4461-4463.
3. Mao J *, Eoh H *, He R, Wang Y, Wan B, Franzblau SG, Crick DC, Kozikowski AP. 2008.
Structure-activity relationships of compounds targeting mycobacterium tuberculosis 1-deoxy-D-xylulose 5-phosphate synthase. Bioorg Med Chem Lett. Oct 1;18(19):5320-3. * Equal contribution.
2. Eoh H, Brown AC, Buetow L, Hunter WN, Parish T, Kaur D, Brennan PJ, Crick DC. 2007. Characterization of the Mycobacterium tuberculosis4-diphosphocytidyl-2-C-methyl-D-erythritol synthase: potential for drug development. J Bacteriol. Dec;189(24):8922-7.
1. Bahk YY, Kim SA, Kim JS, Euh HJ (Eoh H), Bai GH, Cho SN, Kim YS. 2004. Antigens secreted from Mycobacterium tuberculosis: identification by proteomics approach and test for diagnostic marker. Proteomics. Nov;4(11):3299-307.