Hyungjin Eoh Lab

Publications

  1. Eoh H, Wang Z, Layre E, Rath P, Morris R, Branch Moody D, Rhee KY. Metabolic anticipation in Mycobacterium tuberculosis. Nat Microbiol. 2017 May 22;2:17084. doi: 10.1038/nmicrobiol.2017.84.
  1. Puckett S, Trujillo C, Wang Z, Eoh H, Ioerger TR, Krieger I, Sacchettini J, Schnappinger D, Rhee KY, Ehrt S. Glyoxylate detoxification is an essential function of malate synthase required for carbon assimilation in Mycobacterium tuberculosis. Proc Natl Acad Sci U S A. 2017 Mar 14;114(11): E2225-E2232. doi: 10.1073/pnas.1617655114. Epub 2017 Mar 6.
  1. Evans JC, Trujillo C, Wang Z, Eoh H, Ehrt S, Schnappinger D, Boshoff HI, Rhee KY, Barry CE 3rd, Mizrahi V. Validation of CoaBC as a Bactericidal Target in the Coenzyme A Pathway of Mycobacterium tuberculosis. ACS Infect Dis. 2016 Dec 9;2(12):958-968. Epub 2016 Oct 5.
  1. Katragkou A, Alexander EL, Eoh H, Raheem SK, Roilides E, Walsh TJ. Effects of fluconazole on the metabolomic profile of Candida albicans. J Antimicrob Chemother. 2016 Mar;71(3):635-40. doi: 10.1093/jac/dkv381. Epub 2015 Dec 13.
  1. Ganapathy U, Marrero J, Calhoun S, Eoh H, de Carvalho LP, Rhee K, Ehrt S. 2015. Two enzymes with redundant fructose bisphosphatase activity sustain gluconeogenesis and virulence in Mycobacterium tuberculosis. Nature Commun. Aug. 10;6:7912.
  1. Eoh H*. 2014. Metabolomics: a window into the adaptive physiology of Mycobacterium tuberculosis. Tuberculosis (Edinb). Dec;94(6):538-43. Review.*corresponding author.
  1. Puckett S, Trujillo C, Eoh H, Marrero J, Spencer J, Jackson M, Schnappinger D, Rhee K, Ehrt S. 2014. Inactivation of fructose-1,6-bisphosphate aldolase prevents optimal co-catabolism of glycolytic and gluconeogenic carbon substrates in Mycobacterium tuberculosis. PLoS Pathog. 2014 May 22;10(5):e1004144.
  1. Eoh H, Rhee KY. 2014. Methylcitrate cycle defines the bactericidal essentiality of isocitrate lyase for survival of Mycobacterium tuberculosis on fatty acids. Proc Natl Acad Sci U S A. 2014 Apr 1;111(13):4976-81.
  1. Eoh H, Rhee KY. 2014. Allostery and compartmentalization: old but not forgotten. Curr Opin Microbiol. 2014 Apr;18:23-9. Review.
  1. Eoh H, Rhee KY. 2013. Multifunctional essentiality of succinate metabolism in adaptation to hypoxia in Mycobacterium tuberculosis. Proc Natl Acad Sci U S A. Apr 16;110(16):6554-9.
  1. Jeon BY, Eoh H, Ha SJ, Bang H, Kim SC, Sung YC, Cho SN. 2011. Co-immunization of plasmid DNA encoding IL-12 and IL-18 with Bacillus Calmette-Guérin vaccine against progressive tuberculosis. Yonsei Med J. 2011 Nov;52(6):1008-15. 
  1. Woong Park S, Klotzsche M, Wilson DJ, Boshoff HI, Eoh H, Manjunatha U, Blumenthal A, Rhee K, Barry CE 3rd, Aldrich CC, Ehrt S, Schnappinger D. 2011. Evaluating the sensitivity of Mycobacterium tuberculosis to biotin deprivation using regulated gene expression. PLoS Pathog. Sep;7(9):e1002264. 
  1. Jani C*, Eoh H*, Lee JJ*, Hamasha K, Sahana MB, Han JS, Nyayapathy S, Lee JY, Suh JW, Lee SH, Rehse SJ, Crick DC, Kang CM. 2010. Regulation of polar peptidoglycan biosynthesis by Wag31 phosphorylation in mycobacteria. BMC Microbiol. Dec 29;10:327. *Equal author.
  1. Eoh H, Jeon BY, Kim Z, Kim SC, Cho SN. 2010. Expression and validation of D-erythrulose 1-phosphate dehydrogenase from Brucella abortus: a diagnostic reagent for bovine brucellosis. J Vet Diagn Invest. Jul;22(4):524-30.
  1. Narayanasamy P*, Eoh H*, Brennan PJ, Crick DC. 2010. Synthesis of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate and kinetic studies of Mycobacterium tuberculosis IspF. Chem Biol. Feb 26;17(2):117-22. *Equal author.
  1. Eoh H*, Narayanasamy P*, Brown AC, Parish T, Brennan PJ, Crick DC. 2009. Expression and characterization of soluble 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase from bacterial pathogens. Chem Biol. Dec 24;16(12):1230-9. *Equal author.
  1. Eoh H*, Brennan PJ, Crick DC*. 2009. The Mycobacterium tuberculosis MEP (2C-methyl-d-erythritol 4-phosphate) pathway as a new drug target. Tuberculosis (Edinb). Jan;89(1):1-11. *Equal Corresponding author.
  1. Narayanasamy P, Eoh H, Crick DC. 2008. Chemoenzymatic synthesis of 4-diphosphocytidyl-2-C-methyl-D-erythritol: A substrate for IspE. Tetrahedron Lett. Jul 21;49(29-30):4461-4463.
  1. Mao J*, Eoh H*, He R, Wang Y, Wan B, Franzblau SG, Crick DC, Kozikowski AP. 2008. Structure-activity relationships of compounds targeting mycobacterium tuberculosis 1-deoxy-D-xylulose 5-phosphate synthase. Bioorg Med Chem Lett. Oct 1;18(19):5320-3. *Equal author.
  1. Eoh H, Brown AC, Buetow L, Hunter WN, Parish T, Kaur D, Brennan PJ, Crick DC. 2007. Characterization of the Mycobacterium tuberculosis 4-diphosphocytidyl-2-C-methyl-D-erythritol synthase: potential for drug development. J Bacteriol. Dec;189(24):8922-7. 
  1. Bahk YY, Kim SA, Kim JS, Euh HJ (Eoh H), Bai GH, Cho SN, Kim YS. 2004. Antigens secreted from Mycobacterium tuberculosis: identification by proteomics approach and test for diagnostic marker. Proteomics. Nov;4(11):3299-307.