Hyungjin Eoh Lab For

Hyungjin Eoh Lab

Publications

2025

55. Shen KA, Lee JJ, Cheng SY, Tang L, Kwon D, Kokot N, Sinha U, Chai Y, Eoh H, Han AY. Enhanced glycolysis and nucleotide metabolism in HPV-positive head and neck cancer. Sci Rep. 2025 Oct 31 Accepted.

54. Danchik C, Anoushka G.V., Lee GY, Bader J.S., Eoh H, Karakousis P.C. The Phosphate-Specific Transport System Gene pstA1 Contributes to Rifampin Tolerance in Mycobacterium tuberculosis. bioRxiv [Preprint]. 2025 Nov 1. https://www.biorxiv.org/content/10.1101/2025.10.31.685634v1

53. Lee JJ, Swanson DH, Lee SK, Dihardjo S, Lee GY, Gelle S, Seong HJ, Bravo ERM, Taylor ZE, Van Nieuwenhze MS, Singh A, Lee JS, Eum S, Cho S, Swarts BM, Eoh H. Trehalose catalytic shift inherently enhances phenotypic heterogeneity and multidrug resistance in Mycobacterium tuberculosis. Nature Communications. 2025 Jul 11;16(1):6442. https://www.nature.com/articles/s41467-025-61703-3

2024

52. Choi HY, Zhu Y, Zhao X, Mehta S, Hernandez JC, Lee JJ, Kou Y, Machida R, Giacca M, Del Sal G, Ray R, Eoh H, Tahara SM, Chen L, Tsukamoto H, Machida K. Author Correction: NOTCH localizes to mitochondria through the TBC1D15-FIS1 interaction and is stabilized via blockade of E3 ligase and CDK8 recruitment to reprogram tumor-initiating cells. Exp Mol Med. 2024 Oct;56(10):2323.

51. Lee JJ, Swanson D, Lee SK, Dihardjo S, Lee GY, Gelle S, Maskill E, Taylor Z, Nieuwenhze MV, Singh A, Lee JS, Eum SY, Cho SN, Swarts B, Eoh H. Trehalose catalytic shift is an intrinsic factor in Mycobacterium tuberculosis that enhances phenotypic heterogeneity and multidrug resistance. Res Sq [Preprint]. 2024 Sep 13:rs.3.rs-4999164.

50. Liu R, Dang JN, Lee R, Lee JJ, Kesavamoorthy N, Ameri H, Rao N, Eoh H. Mycobacterium dormancy and antibiotic tolerance within the retinal pigment epithelium of ocular tuberculosis. Microbiol Spectr. 2024 Jun 25:e0078824.

49. Liu R, Dang JN, Lee R, Lee JJ, Kesavamoorthy N, Ameri H, Rao N, Eoh H. Mycobacterium dormancy and antibiotic tolerance within the retinal pigment epithelium of ocular tuberculosis. bioRxiv [Preprint]. 2024 Mar 19:2024.03.18.585612.

48. Kalera K, Liu R, Lim J, Pathirage R, Swanson DH, Johnson UG, Stothard AI, Lee JJ, Poston AW, Woodruff PJ, Ronning DR, Eoh Hǂ, Swarts BMǂ. Targeting Mycobacterium tuberculosis Persistence through Inhibition of the Trehalose Catalytic Shift. ACS Infect Dis. 2024 Mar 14. ǂ, corresponding authors

47. Li Y, Wu C, Lee J, Ning Q, Lim J, Eoh H, Wang S, Hurrell BP, Akbari O, Ou JJ. Hepatitis B virus e antigen induces atypical metabolism and differentially regulates programmed cell deaths of macrophages. PLoS Pathog. 2024 Mar 11;20(3):e1012079.

46. Choi HY, Zhu Y, Zhao X, Mehta S, Hernandez JC, Lee JJ, Kou Y, Machida R, Giacca M, Del Sal G, Ray R, Eoh H, Tahara SM, Chen L, Tsukamoto H, Machida K. NOTCH localizes to mitochondria through the TBC1D15-FIS1 interaction and is stabilized via blockade of E3 ligase and CDK8 recruitment to reprogram tumor-initiating cells. Exp Mol Med. 2024 Feb;56(2):461-477.

45. Kim S, Ge J, Kim D, Lee JJ, Choi YJ, Chen W, Bowman JW, Foo SS, Chang LC, Liang Q, Hara D, Choi I, Kim MH, Eoh H, Jung JU. TXNIP-mediated crosstalk between oxidative stress and glucose metabolism. PLoS One. 2024 Feb 8;19(2):e0292655.

2023

44. Sharma R, Hartman TE, Beites T, Kim JH, Eoh H, Engelhart CA, Zhu L, Wilson DJ, Aldrich CC, Ehrt S, Rhee KY, Schnappinger D. Metabolically distinct roles of NAD synthetase and NAD kinase define the essentiality of NAD and NADP in Mycobacterium tuberculosis. mBio. 2023 Aug 31;14(4):e0034023.

43. Sugahara G, Ishida Y, Lee JJ, Li M, Tanaka Y, Eoh H, Higuchi Y, Saito T. Long-term cell fate and functional maintenance of human hepatocyte through stepwise culture configuration. FASEB J. 2023 Feb;37(2):e22750.

2022

42. Eoh Hǂ, Liu R, Lim J, Lee JJ, Sell P. Central carbon metabolism remodeling as a mechanism to develop drug tolerance and drug resistance in Mycobacterium tuberculosis. Front Cell Infect Microbiol. 2022 Aug 22;12:958240. ǂ, corresponding author

41. Choi UY, Lee JJ, Park A, Jung KL, Lee SA, Choi YJ, Lee HR, Lai CJ, Eoh Hǂ, Jung JUǂ. Herpesvirus-induced spermidine synthesis and eIF5A hypusination for viral episomal maintenance. Cell Rep. 2022 Aug 16;40(7):111234. ǂ, corresponding authors

40. Ayoola MB, Shack LA, Lee JH, Lim J, Eoh H, Swiatlo E, Phanstiel O 4th, Nanduri B. Difluoromethylornithine (DFMO) and AMXT 1501 inhibit capsule biosynthesis in pneumococci. Sci Rep. 2022 Jul 12;12(1):11804.

39. Quinonez CG, Lee JJ, Lim J, Odell M, Lawson CP, Anyogu A, Raheem S, Eoh H. Fatty acid metabolism of Mycobacterium tuberculosis: A double-edged sword. Microb Cell. 2022 Feb 28;9(5):123-125.

38. Kim YJ, Lee JY, Lee JJ, Jeon SM, Silwal P, Kim IS, Kim HJ, Park CR, Chung C, Han JE, Choi JW, Tak EJ, Yoo JH, Jeong SW, Kim DY, Ketphan W, Kim SY, Jhun BW, Whang J, Kim JM, Eoh Hǂ, Bae JWǂ, Jo EKǂ. Arginine-mediated gut microbiome remodeling promotes host pulmonary immune defense against nontuberculous mycobacterial infection. Gut Microbes. 2022 Jan-Dec;14(1):2073132. ǂ, corresponding authors

37. Quinonez CG, Lee JJ, Lim J, Odell M, Lawson CP, Anyogu A, Raheem S, Eoh H. The Role of Fatty Acid Metabolism in Drug Tolerance of Mycobacterium tuberculosis. mBio. 2022 Feb 22;13(1):e0355921.

2021

36. Lee H, Lee JJ, Park NY, Dubey SK, Kim T, Ruan K, Lim SB, Park SH, Ha S, Kovlyagina I, Kim KT, Kim S, Oh Y, Kim H, Kang SU, Song MR, Lloyd TE, Maragakis NJ, Hong YBǂ, Eoh Hǂ, Lee Gǂ. Multi-omic analysis of selectively vulnerable motor neuron subtypes implicates altered lipid metabolism in ALS. Nat Neurosci. 2021 Dec;24(12):1673-1685. ǂ, corresponding authors

35. Lim J, Lee JJ, Lee SK, Kim S, Eum SY, Eoh H. Phosphoenolpyruvate depletion mediates both growth arrest and drug tolerance of Mycobacterium tuberculosis in hypoxia. Proc Natl Acad Sci U S A. 2021 Aug 31;118(35):e2105800118.

34. Liboro K, Yu SR, Lim J, So YS, Bahn YS, Eoh H, Park H. Transcriptomic and Metabolomic Analysis Revealed Roles of Yck2 in Carbon Metabolism and Morphogenesis of Candida albicans. Front Cell Infect Microbiol. 2021 Mar 16;11:636834.

2020

33. Luna B, Trebosc V, Lee B, Bakowski M, Ulhaq A, Yan J, Lu P, Cheng J, Nielsen T, Lim J, Ketphan W, Eoh H, McNamara C, Skandalis N, She R, Kemmer C, Lociuro S, Dale GE, Spellberg B. A nutrient-limited screen unmasks rifabutin hyperactivity for extensively drug-resistant Acinetobacter baumannii. Nat Microbiol. 2020 Sep;5(9):1134-1143.

32. Choi UY, Lee JJ, Park A, Zhu W, Lee HR, Choi YJ, Yoo JS, Yu C, Feng P, Gao SJ, Chen S, Eoh Hǂ, Jung JUǂ. Oncogenic human herpesvirus hijacks proline metabolism for tumorigenesis. Proc Natl Acad Sci U S A. 2020 Apr 7;117(14):8083-8093. ǂ, corresponding authors

2019

31.Lee JJ, Lee SK, Song N, Nathan TO, Swarts BM, Eum SY, Ehrt S, Cho SN, Eoh H. Transient drug-tolerance and permanent drug-resistance rely on the trehalose-catalytic shift in Mycobacterium tuberculosis. Nat Commun. 2019 Jul 2;10(1):2928.

30. Dutta NK, Klinkenberg LG, Vazquez MJ, Segura-Carro D, Colmenarejo G, Ramon F, Rodriguez-Miquel B, Mata-Cantero L, Porras-De Francisco E, Chuang YM, Rubin H, Lee JJ, Eoh H, Bader JS, Perez-Herran E, Mendoza-Losana A, Karakousis PC. Inhibiting the stringent response blocks Mycobacterium tuberculosisentry into quiescence and reduces persistence. Sci Adv. 2019 Mar 20;5(3):eaav2104.

2018

29. Eoh H ǂ, Jung JU. Bacterial Protein Reshapes Host Defense toward Antiviral Responses. Mol Cell. 2018 Aug 16;71(4):483-484. doi: 10.1016/j.molcel.2018.08.006.ǂ Corresponding Author.

28. Kim PM, Lee JJ, Choi D, Eoh H ǂ, Hong YK. Endothelial lineage-specific interaction of Mycobacterium tuberculosiswith the blood and lymphatic systems. Tuberculosis (Edinb). 2018 Jul;111:1-7. doi: 10.1016/j.tube.2018.04.009. Epub 2018 May 4. Review.ǂ Corresponding Author.

27. Lee JJ, Lim J, Gao S, Lawson CP, Odell M, Raheem S, Woo J, Kang SH, Kang SS, Jeon BY, Eoh H. Glutamate mediated metabolic neutralization mitigates propionate toxicity in intracellular Mycobacterium tuberculosis. Sci Rep. 2018 May 31;8(1):8506. 

26. Seo GJ, Kim C, Shin WJ, Sklan EH, Eoh H, Jung JU. TRIM56-mediated monoubiquitination of cGAS for cytosolic DNA sensing. Nat Commun. 2018 Feb 9;9(1):613. 

2017

25. Zhu Y, Li T, Ramos da Silva S, Lee JJ, Lu C, Eoh H, Jung JU, Gao SJ. A Critical Role of Glutamine and Asparagine γ-Nitrogen in Nucleotide Biosynthesis in Cancer Cells Hijacked by an Oncogenic Virus. MBio. 2017 Aug 15;8(4). pii: e01179-17. 

24. Wu WL, Grotefend CR, Tsai MT, Wang YL, Radic V, Eoh H, Huang IC. Δ20 IFITM2 differentially restricts X4 and R5 HIV-1. Proc Natl Acad Sci U S A. 2017 Jul 3;114(27):7112-7117. 

23. Eoh H, Wang Z, Layre E, Rath P, Morris R, Branch Moody D, Rhee KY. Metabolic anticipation in Mycobacterium tuberculosis. Nat Microbiol. 2017 May 22;2:17084. 

22. Puckett S, Trujillo C, Wang Z, Eoh H, Ioerger TR, Krieger I, Sacchettini J, Schnappinger D, Rhee KY, Ehrt S. Glyoxylate detoxification is an essential function of malate synthase required for carbon assimilation in Mycobacterium tuberculosis. Proc Natl Acad Sci U S A. 2017 Mar 14;114(11):E2225-E2232. 

2016

21.  Evans JC, Trujillo C, Wang Z, Eoh H, Ehrt S, Schnappinger D, Boshoff HI, Rhee KY, Barry CE 3rd, Mizrahi V.Validation of CoaBC as a Bactericidal Target in the Coenzyme A Pathway of Mycobacterium tuberculosis. ACS Infect Dis. 2016 Oct 5.

20.  Saini V, Cumming BM, Guidry L, Lamprecht DA, Adamson JH, Reddy VP, Chinta KC, Mazorodze JH, Glasgow JN, Richard-Greenblatt M, Gomez-Velasco A, Bach H, Av-Gay Y, Eoh H, Rhee K, Steyn AJ. Ergothioneine Maintains Redox and Bioenergetic Homeostasis Essential for Drug Susceptibility and Virulence of Mycobacterium tuberculosis. Cell Rep. 2016 Jan 26;14(3):572-85.

19.  Katragkou A, Alexander EL, Eoh H, Raheem SK, Roilides E, Walsh TJ. Effects of fluconazole on the metabolomic profile of Candida albicans. J Antimicrob Chemother. 2016 Mar;71(3):635-40.

2015

18. Ganapathy U, Marrero J, Calhoun S, Eoh H, de Carvalho LP, Rhee K, Ehrt S. 2015. Two enzymes with redundant fructose bisphosphatase activity sustain gluconeogenesis and virulence in Mycobacterium tuberculosis. Nature Commun. Aug. 10;6:7912.

Before USC

17. Eoh H ǂ 2014. Metabolomics: a window into the adaptive physiology of Mycobacterium tuberculosis. Tuberculosis (Edinb). Dec;94(6):538-43. Review.ǂ Corresponding Author.

16. Puckett S, Trujillo C, Eoh H, Marrero J, Spencer J, Jackson M, Schnappinger D, Rhee K, Ehrt S. 2014. Inactivation of fructose-1,6-bisphosphate aldolase prevents optimal co-catabolism of glycolytic and gluconeogenic carbon substrates in Mycobacterium tuberculosis. PLoS Pathog. 2014 May 22;10(5):e1004144.

15. Eoh H, Rhee KY. 2014. Methylcitrate cycle defines the bactericidal essentiality of isocitrate lyase for survival of Mycobacterium tuberculosison fatty acids. Proc Natl Acad Sci U S A. 2014 Apr 1;111(13):4976-81.

14. Eoh H, Rhee KY. 2014. Allostery and compartmentalization: old but not forgotten. Curr Opin Microbiol. 2014 Apr;18:23-9. Review.

13. Eoh H, Rhee KY. 2013. Multifunctional essentiality of succinate metabolism in adaptation to hypoxia in Mycobacterium tuberculosis. Proc Natl Acad Sci U S A. Apr 16;110(16):6554-9.

12. Jeon BY, Eoh H, Ha SJ, Bang H, Kim SC, Sung YC, Cho SN. 2011. Co-immunization of plasmid DNA encoding IL-12 and IL-18 with Bacillus Calmette-Guérin vaccine against progressive tuberculosis. Yonsei Med J. 2011 Nov;52(6):1008-15. 

11. Woong Park S, Klotzsche M, Wilson DJ, Boshoff HI, Eoh H, Manjunatha U, Blumenthal A, Rhee K, Barry CE 3rd, Aldrich CC, Ehrt S, Schnappinger D. 2011. Evaluating the sensitivity of Mycobacterium tuberculosisto biotin deprivation using regulated gene expression. PLoS Pathog. Sep;7(9):e1002264. 

10. Jani C *, Eoh H *, Lee JJ *, Hamasha K, Sahana MB, Han JS, Nyayapathy S, Lee JY, Suh JW, Lee SH, Rehse SJ, Crick DC, Kang CM. 2010. Regulation of polar peptidoglycan biosynthesis by Wag31 phosphorylation in mycobacteria. BMC Microbiol. Dec 29;10:327. * Equal contribution.

9. Eoh H, Jeon BY, Kim Z, Kim SC, Cho SN. 2010. Expression and validation of D-erythrulose 1-phosphate dehydrogenase from Brucella abortus: a diagnostic reagent for bovine brucellosis. J Vet Diagn Invest. Jul;22(4):524-30.

8. Narayanasamy P *, Eoh H *, Brennan PJ, Crick DC. 2010. Synthesis of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate and kinetic studies of Mycobacterium tuberculosis IspF. Cell Chem Biol. Feb 26;17(2):117-22. *Equal contribution.

7. Eoh H *, Narayanasamy P *, Brown AC, Parish T, Brennan PJ, Crick DC. 2009. Expression and characterization of soluble 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase from bacterial pathogens. Cell Chem Biol. Dec 24;16(12):1230-9. * Equal contribution.

6. Eoh H ǂ, Brennan PJ, Crick DC ǂ. 2009. The Mycobacterium tuberculosisMEP (2C-methyl-d-erythritol 4-phosphate) pathway as a new drug target. Tuberculosis (Edinb). Jan;89(1):1-11. ǂ Corresponding authors.

5. Narayanasamy P, Eoh H, Crick DC. 2008. Chemoenzymatic synthesis of 4-diphosphocytidyl-2-C-methyl-D-erythritol: A substrate for IspE. Tetrahedron Lett. Jul 21;49(29-30):4461-4463.

4. Mao J *, Eoh H *, He R, Wang Y, Wan B, Franzblau SG, Crick DC, Kozikowski AP. 2008. 

3. Structure-activity relationships of compounds targeting mycobacterium tuberculosis 1-deoxy-D-xylulose 5-phosphate synthase. Bioorg Med Chem Lett. Oct 1;18(19):5320-3. * Equal contribution.

2. Eoh H, Brown AC, Buetow L, Hunter WN, Parish T, Kaur D, Brennan PJ, Crick DC. 2007. Characterization of the Mycobacterium tuberculosis4-diphosphocytidyl-2-C-methyl-D-erythritol synthase: potential for drug development. J Bacteriol. Dec;189(24):8922-7. 

1. Bahk YY, Kim SA, Kim JS, Euh HJ (Eoh H), Bai GH, Cho SN, Kim YS. 2004. Antigens secreted from Mycobacterium tuberculosis: identification by proteomics approach and test for diagnostic marker. Proteomics. Nov;4(11):3299-307.