* Selected Publications

Click here for a complete PubMed search for Pinghui Feng.


Innate Immune Signaling in Response to Viral Infection

A Viral Deamidase Targets the Helicase Domain of RIG-I to Block RNA-Induced Activation.

Zhao J, Zeng Y, Xu S, Chen J, Shen G, Yu C, Knipe D, Yuan W, Peng J, Xu W, Zhang C, Xia Z, Feng P.

Cell Host Microbe. 2016 Dec 14;20(6):770-784.

IκB Kinase ε Is an NFATc1 Kinase that Inhibits T Cell Immune Response.

Zhang J, Feng H, Zhao J, Feldman ER, Chen SY, Yuan W, Huang C, Akbari O, Tibbetts SA, Feng P.

Cell Rep. 2016 Jul 12;16(2):405-18.

An Internally Translated MAVS Variant Exposes Its Amino-terminal TRAF-Binding Motifs to Deregulate Interferon Induction.

Minassian A, Zhang J, He S, Zhao J, Zandi E, Saito T, Liang C, Feng P.

PLoS Pathog. 2015 Jul 29;11(7):e1005060.

Viral pseudo-enzymes activate RIG-I via deamidation to evade cytokine production.

He S, Zhao J, Song S, He X, Minassian A, Zhou Y, Zhang J, Brulois K, Wang Y, Cabo J, Zandi E, Liang C, Jung JU, Zhang X, Feng P.

Mol Cell. 2015 Apr 2;58(1):134-46.

NF-κB activation coordinated by IKKβ and IKKε enables latent infection of Kaposi’s sarcoma-associated herpesvirus.

He Z, Zhao J, Zhang J, Jung JU, Feng P.

J Virol. 2014 Jan;88(1):444-55.

Murine gammaherpesvirus 68 evades host cytokine production via replication transactivator-induced RelA degradation.

Dong X, He Z, Durakoglugil D, Arneson L, Shen Y, Feng P.

J Virol. 2012 Feb;86(4):1930-41.

Murine gamma herpesvirus 68 hijacks MAVS and IKKβ to abrogate NFκB activation and antiviral cytokine production.

Dong X, Feng P.

PLoS Pathog. 2011 Nov;7(11):e1002336.

Murine gamma-herpesvirus 68 hijacks MAVS and IKKbeta to initiate lytic replication.

Dong X, Feng H, Sun Q, Li H, Wu TT, Sun R, Tibbetts SA, Chen ZJ, Feng P.

PLoS Pathog. 2010 Jul 29;6(7):e1001001.


Viral Oncogenesis

Recombinant Murine Gamma Herpesvirus 68 Carrying KSHV G Protein-Coupled Receptor Induces Angiogenic Lesions in Mice.

Zhang J, Zhu L, Lu X, Feldman ER, Keyes LR, Wang Y, Fan H, Feng H, Xia Z, Sun J, Jiang T, Gao SJ, Tibbetts SA, Feng P.

PLoS Pathog. 2015 Jun 24;11(6):e1005001.

Herpesviral G protein-coupled receptors activate NFAT to induce tumor formation via inhibiting the SERCA calcium ATPase.

Zhang J, He S, Wang Y, Brulois K, Lan K, Jung JU, Feng P.

PLoS Pathog. 2015 Mar 26;11(3):e1004768.

Dissecting innate immune signaling in viral evasion of cytokine production.

Zhang J, Zhu L, Feng P.

J Vis Exp. 2014 Mar 2;(85).

IKK epsilon kinase is crucial for viral G protein-coupled receptor tumorigenesis.

Wang Y, Lu X, Zhu L, Shen Y, Chengedza S, Feng H, Wang L, Jung JU, Gutkind JS, Feng P.

Proc Natl Acad Sci U S A. 2013 Jul 2;110(27):11139-44.

Invited Reviews

Roles of IκB kinase ε in the innate immune defense and beyond.

Zhang J, Tian M, Xia Z, Feng P.

Virol Sin. 2016 Dec;31(6):457-465

Hijacking GPCRs by viral pathogens and tumor.

Zhang J, Feng H, Xu S, Feng P.

Biochem Pharmacol. 2016 Aug 15;114:69-81.

Emerging Roles of Protein Deamidation in Innate Immune Signaling.

Zhao J, Li J, Xu S, Feng P.

J Virol. 2016 Apr 14;90(9):4262-8.

Recent advances on viral manipulation of NF-κB signaling pathway.

Zhao J, He S, Minassian A, Li J, Feng P.

Curr Opin Virol. 2015 Dec;15:103-11.

Evasion of adaptive and innate immune response mechanisms by γ-herpesviruses.

Feng P, Moses A, Früh K.

Curr Opin Virol. 2013 Jun;3(3):285-95.