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Laboratory of Chemical Carcinogenesis and Molecular Oncology

Joseph R. Landolph, Jr., received a B. S. degree in Chemistry from Drexel Univ. in Phila., Pa., (l971) and a Ph. D. in Chemistry (Physical/Biophysical Chemistry), from Univ. of Calif. at Berkeley in Berkeley, Calif., (l976), under Prof. M. Calvin (Member, U. S. Nat’l. Acad. Sci./Nobel Laureate).  For his Ph. D., he studied the metabolism of the carcinogen, benzo(a)pyrene (BaP), and BaP-induced cytotoxicity and morphological/-neoplastic transformation in cultured mouse liver epithelial cells and Balb/c 3T3 mouse fibroblasts.  He performed postdoctoral study in chemically induced mutagenesis, morphological/ neoplastic cell transformation, and carcinogenesis at the USC/Norris Comprehensive Cancer Center, Keck School of Medicine, Univ. of Southern Calif. (USC) (l977-l980), under Prof. C. Heidelberger (member, U. S. Nat’l. Acad. Sci.).

Dr. Landolph was appointed Asst. Prof. of Microbiol./Pathol. in l982, and is currently Assoc. Prof. of Molecular Microbiol./Immunol. and Pathology and a Member of the USC/Norris Comprehensive Cancer Center in the Keck School of Medicine, Assoc. Prof. of Molec. Pharmacology/Pharm. Sciences in the School of Pharmacy, and a Member of the Free Radical Institute, at USC.  His research interests include studies of the genetic toxicology/carcinogenicity of carcinogenic nickel (Ni), chromium (VI), and arsenic compounds and P. A. H.s. 

His laboratory studies the ability of carcinogenic Ni and chromium (VI) compounds to induce morphological/neoplastic transformation of 10T1/2 mouse embryo cells and diploid human fibroblasts, and activation of oncogenes/ inactivation of tumor suppressor genes and de-regulation of global gene expression, in Ni-transformed cell lines. He is an expert in chemically induced mutation and morphological/neoplastic transformation in murine/ human fibroblasts. He has authored 68 scientific publications, given 204 invited scientific lectures, trained 105 B. S. students, 29 M. S. students, 5 M. D.  students, 13 Ph. D. students, and 32 postdoctoral fellows, and hosted 10 faculty and 4 high school teachers on sabbaticals.  Dr. Landolph served as a grant reviewer for U. S. E.P.A.’s Health Effects Panel, for NIEHS, and for the Chemical Pathology and Al-Tox-4 Study Sections of NIH.  He also served as a member of the Carcinogen Identification Committee of California’s Office of Environmental Health Hazard Assessment of California’s E. P. A. (1994-Present), and as a member of the Scientific Review Panel for Toxic Air Contaminants of the Calif. Air Resources Board (2003-2010).  He also served on the Drinking Water (2003-2009) and Human Health Res. Review (2003) Committees of the Science Advisory Board of U. S. E. P. A., as a member of the Human Health Res. Rev. Sub-Committee of the Board of Scientific Counselors of U. S. E. P. A. (2005-2006), and as a member of the Nat. Acad. of Sciences Panel to review U. S. E. P. A.’s PCE Risk Assessment (2009-2010).  He received numerous awards, including: Merck Award in Chem./Superior Cadet Award in ROTC from Drexel Univ. in l971, American Canc. Soc. Postdoctoral Fellowship (l977-l979), Edmundson Teaching Award in Dept. of Pathology at USC (l985), and a Traveling Lectureship Award from U. S. Soc. of Toxicology (l990).  He has held peer-reviewed research grant support from U. S. EPA, N. C. I, and N. I. E. H. S.  His biography is published in Who’s Who in CA.; Who’s Who in Frontiers of Sci./ Technol.; International Who’s Who in Medicine;  American Men/Women of Science; Who’s Who of Emerging Leaders in America; Who’s Who in America; Men of Achievement; Who’s Who in American Education; 2,000 Notable American Men; Who’s Who in Medicine/ Healthcare; Who’s Who in the World; International Profiles of Accomplished Leaders.