Selected Publications

 

  1. Sir, D., Tian, Y., Chen, W.-L., Ann, D.K., Yen, T.S.B. and Ou, J.H.J. (2010) The early autophagic pathway is activated by hepatitis B virus and required for viral DNA replication. Natl. Acad. Sci. USA 107:4383-4388. (PMCID: 2840127)

http://www.pnas.org/content/107/9/4383.long

 

  1. Machida, K., Tsukamoto, H., Liu, J.-C., Han, Y.-P., Govindarajan, S., Lai, M.M.C., Akira, S., and Ou, J.H.J. (2010) c-Jun mediates HCV hepatocarcinogenesis through STAT3 and nitric oxide-dependent impairment of oxidative DNA repair. Hepatology 52:480-492. (PMCID:3107125)

http://onlinelibrary.wiley.com/doi/10.1002/hep.23697/abstract;jsessionid=8099CE39D47D1F1F1EFADC4F0512C524.f04t04

 

  1. Tian, Y., Chen, W.-L., and Ou, J.H.J. (2011) Effects of interferon-a/b on HBV replication determined by viral load. PLoS Pathogens 7(7):e1002159. (PMCID:3145790)

http://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1002159

 

  1. Sun, J., Desai, M.M., Soong, L. and Ou, J.H.J. (2011) IFN-a/b and autophagy: tug-of-war between HCV and the host. Autophagy 7(11):1394-1396. (PMCID:3359484)

http://www.tandfonline.com/doi/full/10.4161/auto.7.11.17514

 

  1. Tian, Y., Sir, D., Kuo, C.-F., Ann, D.K. and Ou, J.H.J. (2011) Autophagy required for HBV replication in transgenic mice. Virol. 85:13453-13456 (Spotlight of the issue) (PMCID:3233133)

http://jvi.asm.org/content/85/24/13453.long

 

  1. Tian, Y., Kuo, C.-F., Chen, W.-L. and Ou, J.H.J. (2012) Enhancement of hepatitis B virus replication by androgen and its receptor in mice. Virol. 86:1904-1910. (Selected for ASM Press Release on 2/16/2012) (PMCID: 3302417)

http://jvi.asm.org/content/86/4/1904.long

 

  1. Sir, D., Kuo, C.-F, Tian, Y., Liu, H.M., Huang, E.J., Jung, J.U., Machida, K., and Ou, J.H.J. (2012) Replication of hepatitis C virus RNA on autophagosomal membranes. Biol. Chem. 287(22):18036-18043. (PMCID:3365724)

http://www.jbc.org/content/287/22/18036.long

 

  1. Tian, Y., Chen, W.-L., Kuo, C.-F. and Ou, J.H.J. (2012) Viral load-dependent effects of liver injury and regeneration on HBV replication in mice. Virol. 86:9599-9605. (PMCID:3446606)

http://jvi.asm.org/content/86/18/9599.long

 

  1. Liu, Z., Tian, Y., Machida, K., Lai, M.M.C., Luo, G., Foung, S.K.H., and Ou, J.H.J. (2012) Transient activation of the PI3K-AKT pathway by HCV to enhance viral entry. Biol. Chem. 287:41922-41930. (PMCID:3516739)

http://www.jbc.org/content/287/50/41922.long

 

  1. Ou, J.H.J. (2014) Virus control goes epigenetic. PLoS Pathogens 10(9):e1004370. (PMCID:4161466)

http://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1004370

 

  1. Wang, L., Tian, Y. and Ou, J.H.J. (2015) HCV induces the expression of Rubicon and UVRAG to temporally regulate the maturation of autophagosomes and viral replication. PLoS Pathogens 11(3):e1004764. (PMCID:4373777)

http://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1004764

 

  1. Tian, Y., Kuo, C.-F., Sir, D., Wang, L., Govindarajan, S., Petrovic, L.M. and Ou, J.H.J. (2015) Autophagy inhibits oxidative stress and tumor suppressors to exert its dual effect on hepatocarcinogenesis. Cell Death Diff. 22(6):1025-1034. (PMCID:4423188)

http://www.nature.com/cdd/journal/v22/n6/full/cdd2014201a.html

 

  1. Lee, J., Tian, Y., Chan, S., Cho, C. and Ou, J.H.J. (2015) TNF-α induced by HCV via TLR7 and TLR8 in its host cells supports interferon-signaling via an autocrine mechanism. PLoS Pathogens 11(5):e1004937. (PMCID:4449221)

http://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1004937

 

  1. Tian, Y., Wang, L. and Ou, J.H.J. (2015) Autophagy, a double-edged sword in hepatocarcinogenesis. Cell. Oncology 2:4, e1004968. (PMCID:4905348)

http://www.tandfonline.com/doi/full/10.1080/23723556.2015.1004968

 

  1. Wang, L., and Ou, J.H.J. (2015) Hepatitis C virus and autophagy. Chem. 396(11): 1215-1222. (PMCID:4778564)

http://www.degruyter.com/view/j/bchm.2015.396.issue-11/hsz-2015-0172/hsz-2015-0172.xml

 

  1. Tian, Y., Kuo, C.-F., Akbari, O., and Ou, J.H.J. (2016) Maternal-derived hepatitis B virus e antigen alters macrophage function in offspring to drive viral persistence after vertical transmission. Immunity 44:1204-1214. (PMCID:4871724)

http://www.sciencedirect.com/science/article/pii/S1074761316301376

 

  1. Chan, S., Lee, J., Narula, M. and Ou, J.H.J. (2016) Suppression of host innate immune response by hepatitis C virus via the induction of autophagic degradation of TRAF6. J. Virol. 2016 Sep 28. pii: JVI.01365-16. [Epub ahead of print]

http://jvi.asm.org/content/early/2016/09/22/JVI.01365-16.long