Selected Publications


  1. Sir, D., Tian, Y., Chen, W.-L., Ann, D.K., Yen, T.S.B. and Ou, J.H.J. (2010) The early autophagic pathway is activated by hepatitis B virus and required for viral DNA replication. Natl. Acad. Sci. USA 107:4383-4388. (PMCID: 2840127)


  1. Machida, K., Tsukamoto, H., Liu, J.-C., Han, Y.-P., Govindarajan, S., Lai, M.M.C., Akira, S., and Ou, J.H.J. (2010) c-Jun mediates HCV hepatocarcinogenesis through STAT3 and nitric oxide-dependent impairment of oxidative DNA repair. Hepatology 52:480-492. (PMCID:3107125);jsessionid=8099CE39D47D1F1F1EFADC4F0512C524.f04t04


  1. Tian, Y., Chen, W.-L., and Ou, J.H.J. (2011) Effects of interferon-a/b on HBV replication determined by viral load. PLoS Pathogens 7(7):e1002159. (PMCID:3145790)


  1. Sun, J., Desai, M.M., Soong, L. and Ou, J.H.J. (2011) IFN-a/b and autophagy: tug-of-war between HCV and the host. Autophagy 7(11):1394-1396. (PMCID:3359484)


  1. Tian, Y., Sir, D., Kuo, C.-F., Ann, D.K. and Ou, J.H.J. (2011) Autophagy required for HBV replication in transgenic mice. Virol. 85:13453-13456 (Spotlight of the issue) (PMCID:3233133)


  1. Tian, Y., Kuo, C.-F., Chen, W.-L. and Ou, J.H.J. (2012) Enhancement of hepatitis B virus replication by androgen and its receptor in mice. Virol. 86:1904-1910. (Selected for ASM Press Release on 2/16/2012) (PMCID: 3302417)


  1. Sir, D., Kuo, C.-F, Tian, Y., Liu, H.M., Huang, E.J., Jung, J.U., Machida, K., and Ou, J.H.J. (2012) Replication of hepatitis C virus RNA on autophagosomal membranes. Biol. Chem. 287(22):18036-18043. (PMCID:3365724)


  1. Tian, Y., Chen, W.-L., Kuo, C.-F. and Ou, J.H.J. (2012) Viral load-dependent effects of liver injury and regeneration on HBV replication in mice. Virol. 86:9599-9605. (PMCID:3446606)


  1. Liu, Z., Tian, Y., Machida, K., Lai, M.M.C., Luo, G., Foung, S.K.H., and Ou, J.H.J. (2012) Transient activation of the PI3K-AKT pathway by HCV to enhance viral entry. Biol. Chem. 287:41922-41930. (PMCID:3516739)


  1. Ou, J.H.J. (2014) Virus control goes epigenetic. PLoS Pathogens 10(9):e1004370. (PMCID:4161466)


  1. Wang, L., Tian, Y. and Ou, J.H.J. (2015) HCV induces the expression of Rubicon and UVRAG to temporally regulate the maturation of autophagosomes and viral replication. PLoS Pathogens 11(3):e1004764. (PMCID:4373777)


  1. Tian, Y., Kuo, C.-F., Sir, D., Wang, L., Govindarajan, S., Petrovic, L.M. and Ou, J.H.J. (2015) Autophagy inhibits oxidative stress and tumor suppressors to exert its dual effect on hepatocarcinogenesis. Cell Death Diff. 22(6):1025-1034. (PMCID:4423188)


  1. Lee, J., Tian, Y., Chan, S., Cho, C. and Ou, J.H.J. (2015) TNF-α induced by HCV via TLR7 and TLR8 in its host cells supports interferon-signaling via an autocrine mechanism. PLoS Pathogens 11(5):e1004937. (PMCID:4449221)


  1. Tian, Y., Wang, L. and Ou, J.H.J. (2015) Autophagy, a double-edged sword in hepatocarcinogenesis. Cell. Oncology 2:4, e1004968. (PMCID:4905348)


  1. Wang, L., and Ou, J.H.J. (2015) Hepatitis C virus and autophagy. Chem. 396(11): 1215-1222. (PMCID:4778564)


  1. Tian, Y., Kuo, C.-F., Akbari, O., and Ou, J.H.J. (2016) Maternal-derived hepatitis B virus e antigen alters macrophage function in offspring to drive viral persistence after vertical transmission. Immunity 44:1204-1214. (PMCID:4871724)


  1. Chan, S., Lee, J., Narula, M. and Ou, J.H.J. (2016) Suppression of host innate immune response by hepatitis C virus via the induction of autophagic degradation of TRAF6. J. Virol. 2016 Sep 28. pii: JVI.01365-16. [Epub ahead of print]