Publications

2025
  • Barbetta, A. et al. Integrated workflow for analysis of immune enriched spatial proteomic data with IMmuneCite. Scientific Reports 15, 9394 (2025).
  • Cain, J., Hurrell, B. & Akbari, O. The Expanding Role of ILC2s in Allergic Airways Disease. Allergy(2025).
  • Chandan, G. et al. Perinatal Flavored E-cigarette Exposure and the Critical Role of Innate Lymphoid type II Cells in Transgenerational Asthma Transmission. Journal of Allergy and Clinical Immunology 155, AB442 (2025).
  • Chandan, G. et al. Transgenerational Asthma Risk Induced by Perinatal E-cigarette Exposure: Role of Pulmonary Innate Lymphoid Type II Cells. American Journal of Respiratory and Critical Care Medicine211, A3436-A3436 (2025).
  • Hempel, S. et al. Multiple chemical sensitivity (MCS) validity, prevalence, tools and interventions: systematic review protocol. BMJ open 15, e088136 (2025).
  • Hurrell, B.P. et al. The hidden role of iron: unlocking new therapies for asthma and beyond 9432. The Journal of Immunology 214, vkaf283. 2831 (2025).
  • Kazemi, M.H. et al. FOXO1 pathway activation by VISTA immune checkpoint restrains pulmonary ILC2 functions. The Journal of Clinical Investigation 135 (2025).
  • Kazemi, M.H. et al. VISTA regulates lung ILC2 metabolism and effector function through FOXO1 2223. The Journal of Immunology 214, vkaf283. 166 (2025).
  • Lotfi, N. et al. Enhancing Lung Autophagy Could be a Preventive Strategy Against Maternal E-Cigarette-Associated Offspring Pulmonary Morbidity. Journal Of Investigative Medicine 2025: Sage Publications Ltd; 2025. P. 80-81.
  • Lotfi, N. et al. Improving Lung Autophagy May Serve as a Potential Approach to Reducing Chronic Pulmonary Diseases Associated With Exposure to E-cigarettes. American Journal of Respiratory and Critical Care Medicine 211, A3403-A3403 (2025).
  • Prins, R., Fernandez, D.J., Akbari, O., Da Silva, D.M. & Kast, W.M. HPV16 E6 and E7 expressing cancer cells suppress the antitumor immune response by upregulating KLF2-mediated IL-23 expression in macrophages. Journal for Immunotherapy of Cancer 13, e011915 (2025).
  • Quach, C. et al. BTLA agonist attenuates Th17-driven inflammation in a mouse model of steroid-resistant asthma. Frontiers in Immunology 16, 1552394 (2025).
  • Sakano, K. et al. Targeting CD48 Ameliorates ILC2-mediated Airway Hyperreactivity by Disrupting the PKCβ Pathway. American Journal of Respiratory Cell and Molecular Biology (2025).
  • Sakano, K. et al. CD48 regulates ILC2 effector function and lung inflammation through the PKCß pathway 2049. The Journal of Immunology 214, vkaf283. 019 (2025).
  • Sakano, Y. et al. The potential of signal regulatory protein alpha as a therapeutic target for airway hyperreactivity 9433. The Journal of Immunology 214, vkaf283. 2832 (2025).
  • Sakano, Y. et al. ICOS regulates IL-10 production in group 2 innate lymphoid cells via cholesterol and cortisol biosynthesis. The Journal of Clinical Investigation 135 (2025).
  • Shen, S., Li, X., Hurrell, B.P., Sakano, Y. & Akbari, O. Piezo1 channels orchestrate ILC2-dependent lung inflammation and development of airway hyperreactivity 9431. The Journal of Immunology 214, vkaf283. 2830 (2025).

2024

  • Aguilar, D. et al. Sensory neurons regulate stimulus-dependent humoral immunity. bioRxiv, 2024.2001. 2004.574231 (2024).
  • Aguilar, D. et al. Sensory neurons regulate stimulus-dependent humoral immunity in mouse models of bacterial infection and asthma. Nature Communications 15, 8914 (2024).
  • Barbetta, A. et al. IMmuneCite: an integrated workflow for analysis of immune enriched spatial proteomic data. Research Square, rs. 3. rs-4571625 (2024).
  • Barbetta, A. et al. Spatially resolved immune exhaustion within the alloreactive microenvironment predicts liver transplant rejection. Science Advances 10, eadm8841 (2024).
  • Chandan, G. et al. Pulmonary Innate Lymphoid Type II Cells in Perinatal Vaping-induced Asthma in Offspring. American Thoracic Society, 2024, Pp A6998-A6998.
  • Hurrell, B.P. et al. Iron controls the development of airway hyperreactivity by regulating ILC2 metabolism and effector function. Science Translational Medicine 16, eadk4728 (2024).
  • Hurrell, B.P. et al. Piezo1 channels restrain ILC2s and regulate the development of airway hyperreactivity. Journal of Experimental Medicine 221, e20231835 (2024).
  • Li, Y. et al. Hepatitis B virus e antigen induces atypical metabolism and differentially regulates programmed cell deaths of macrophages. PLoS Pathogens 20, e1012079 (2024).
  • Rocque, B. et al. Technical optimization of spatially resolved single-cell transcriptomic datasets to study clinical liver disease. Scientific reports 14, 3612 (2024).
  • Sakano, Y. et al. Blocking CD226 regulates ILC2 effector function and alleviates airway hyperreactivity: 440. Journal of Allergy & Clinical Immunology 153, AB141 (2024).
  • Sakano, Y. et al. Blocking CD226 regulates type 2 innate lymphoid cell effector function and alleviates airway hyperreactivity. Journal of Allergy and Clinical Immunology 153, 1406-1422. e1406 (2024).
  • Sakano, Y. et al. SIRPα engagement regulates ILC2 effector function and alleviates airway hyperreactivity via modulating energy metabolism. Cellular & Molecular Immunology 21, 1158-1174 (2024).
  • Shafiei-Jahani, P. et al. CB2 stimulation of adipose resident ILC2s orchestrates immune balance and ameliorates type 2 diabetes mellitus. Cell reports 43 (2024).
  • Silverstein, A. et al. Mitochondrial gene signatures illuminate mitochondrial function as an important contributor to post-COVID recovery and long COVID

2023

  • Allan-Blitz, L.-T. et al. Unique immune and inflammatory cytokine profiles may define long COVID syndrome. Clinical and Experimental Medicine 23, 2925-2930 (2023).
  • Allan-Blitz, L.-T., Goodrich, J., Hu, H., Akbari, O. & Klausner, J.D. Altered Tumor Necrosis Factor Response in Neurologic Postacute SARS-CoV-2 Syndrome. Journal of Interferon & Cytokine Research 43, 307-313 (2023).
  • Barbers, R.G. et al. ILC2s With Tnfr2 Expression Are Potential Therapeutic Targets For Asthma. Chest 164, A4904 (2023).
  • Choi, Y.J. et al. Lung-specific MCEMP1 functions as an adaptor for KIT to promote SCF-mediated mast cell proliferation. Nature communications 14, 2045 (2023).
  • Helou, D.G. et al. Human PD-1 agonist treatment alleviates neutrophilic asthma by reprogramming T cells. Journal of Allergy and Clinical Immunology 151, 526-538. e528 (2023).
  • Helou, D.G. et al. LAIR-1 limits macrophage activation in acute inflammatory lung injury. Mucosal immunology16, 788-800 (2023).
  • Hempel, S. et al. Multiple chemical sensitivity scoping review protocol: overview of research and MCS construct. BMJ open 13, e072098 (2023).
  • Howard, E. et al. Orai inhibition modulates pulmonary ILC2 metabolism and alleviates airway hyperreactivity in murine and humanized models. Nature Communications 14, 5989 (2023).
  • Quach, C. et al. Enhancing autophagy in CD11c+ antigen-presenting cells as a therapeutic strategy for acute respiratory distress syndrome. Cell reports 42 (2023).

2022

  • Galle-Treger, L. et al. Autophagy impairment in liver CD11c+ cells promotes non-alcoholic fatty liver disease through production of IL-23. Nature Communications 13, 1440 (2022).
  • Helou, D.G. et al. LAIR-1 acts as an immune checkpoint on activated ILC2s and regulates the induction of airway hyperreactivity. Journal of Allergy and Clinical Immunology 149, 223-236. e226 (2022).
  • Helou, G.D. et al. PD-1 agonist modulates ILC2 metabolism and ameliorates airway hyperreactivity. The Journal of Immunology 208, 109.115-109.115 (2022).
  • Howard, E.D. et al. PD-1 inhibition on pulmonary ILC2s promotes TNF-α production and restricts progression of metastatic melanoma tumor growth. The Journal of Immunology 208, 163.107-163.107 (2022).
  • Hurrell, B.P. et al. PD-L2 controls peripherally induced regulatory T cells by maintaining metabolic activity and Foxp3 stability. Nature Communications 13, 5118 (2022).
  • Hurrell, B.P. et al. Cannabinoid receptor 2 engagement promotes group 2 innate lymphoid cell expansion and enhances airway hyperreactivity. Journal of Allergy and Clinical Immunology 149, 1628-1642. e1610 (2022).
  • Hurrell, B.P. et al. CB2 engagement enhances group 2 innate lymphoid cell expansion and induction of airway hyperreactivity. The Journal of Immunology 208, 109.114-109.114 (2022).
  • Li, Y., Lee, J., Helou, D.G., Akbari, O. & Ou, J.-h.J. Analysis of the interplay between hepatitis B virus-positive hepatocytes and Kupffer cells ex vivo using mice as a model. STAR protocols 3, 101364 (2022).
  • Rahman, M.M. et al. Near-roadway air pollution, immune cells and adipokines among obese young adults. Environmental Health 21, 36 (2022).
  • Rocque, B. et al. Single Cell Multiomics Reveals Immune Mediators in Acute Cellular Rejection Following Pediatric Liver Transplantation. American Journal Of Transplantation 2022: Wiley. P. 538-538.
  • Sarode, D. et al. Temporal Changes in the Peripheral Immune Profile of Acute Rejection Highlight New Mechanisms of Alloimmunity and Potential Non-Invasive Biomarkers of Rejection in Pediatric Liver Transplantation. American Journal Of Transplantation 2022: WILEY. p. 494-495.
  • Ung, N. et al. Adaptation of imaging mass cytometry to explore the single cell alloimmune landscape of liver transplant rejection. Frontiers in immunology 13, 831103 (2022).

2021

  • Baban, B. et al. AMPK induces regulatory innate lymphoid cells after traumatic brain injury. JCI insight 6, e126766 (2021).
  • Emamaullee, J. et al. Multiplexed Imaging Mass Cytometry of the Alloimmune Landscape of Rejection in Clinical Liver Transplantation. American Journal Of Transplantation 2021: Wiley. P. 348-348.
  • Hirose, S. et al. Impact of a demyelination-inducing central nervous system virus on expression of demyelination genes in type 2 lymphoid cells. Journal of Virology 95, 10.1128/jvi. 01934-01920 (2021).
  • Hirose, S. et al. Correction for Hirose et al.,“Impact of a Demyelination-Inducing Central Nervous System Virus on Expression of Demyelination Genes in Type 2 Lymphoid Cells”. Journal of Virology 95, 10.1128/jvi. 00209-00221 (2021).
  • Howard, E. et al. PD-1 blockade on tumor microenvironment-resident ILC2s promotes TNF-α production and restricts progression of metastatic melanoma. Frontiers in Immunology 12, 733136 (2021).
  • Howard, E. et al. IL-10 production by ILC2s requires Blimp-1 and cMaf, modulates cellular metabolism, and ameliorates airway hyperreactivity. Journal of Allergy and Clinical Immunology 147, 1281-1295. e1285 (2021).
  • Matundan, H.H., Jaggi, U., Yu, J., Akbari, O. & Ghiasi, H. Absence of CD28-CTLA4-PD-L1 costimulatory molecules reduces herpes simplex virus 1 reactivation. Mbio 12, 10.1128/mbio. 01176-01121 (2021).
  • Painter, J.D. & Akbari, O. Type 2 innate lymphoid cells: protectors in type 2 diabetes. Frontiers in Immunology12, 727008 (2021).
  • Rocque, B. et al. Analysis of Single Cell RNA Sequencing Data to Define Biomarkers of Human Liver Immune Tolerance. American Journal Of Transplantation 2021: Wiley. P. 582-583.
  • Rocque, B. et al. Creation of a single cell RNASeq meta-atlas to define human liver immune homeostasis. Frontiers in immunology 12, 679521 (2021).
  • Shafiei-Jahani, P. et al. CD52-targeted depletion by Alemtuzumab ameliorates allergic airway hyperreactivity and lung inflammation. Mucosal immunology 14, 899-911 (2021).
  • Shafiei-Jahani, P. et al. CD200–CD200R immune checkpoint engagement regulates ILC2 effector function and ameliorates lung inflammation in asthma. Nature communications 12, 2526 (2021).

2020

  • Emamaullee, J. et al. Multiplexed Imaging Mass Cytometry Analysis Reveals a New Role for CD68+ Macrophages in Chronic Liver Transplant Rejection. American Journal Of Transplantation 2020: Wiley. P. 324-324.
  • Galle, L. et al. Autophagy is critical for group 2 innate lymphoid cell metabolic homeostasis and effector function. The Journal of Immunology 204, 147.143-147.143 (2020).
  • Galle-Treger, L. et al. Autophagy is critical for group 2 innate lymphoid cell metabolic homeostasis and effector function. Journal of Allergy and Clinical Immunology 145, 502-517. e505 (2020).
  • Gilmore, W. et al. Repopulation of T, B, and NK cells following alemtuzumab treatment in relapsing-remitting multiple sclerosis. Journal of Neuroinflammation 17, 189 (2020).
  • Han, Y. et al. Genome-wide analysis highlights contribution of immune system pathways to the genetic architecture of asthma. Nature communications 11, 1776 (2020).
  • Helou, D.G. et al. PD-1 pathway regulates ILC2 metabolism and PD-1 agonist treatment ameliorates airway hyperreactivity. Nature communications 11, 3998 (2020).
  • Hirose, S. et al. Type 2 innate lymphoid cells induce CNS demyelination in an HSV-IL-2 mouse model of multiple sclerosis. Iscience 23 (2020).
  • Howard, E.D. et al. Phenotype-driven screening of 150 strains of mice for allergic lung inflammation identified strains representative of heterogeneous human asthma cohorts. The Journal of Immunology 204, 65.61-65.61 (2020).
  • Hurrell, B.P. et al. TNFR2 signaling enhances ILC2 survival, function and induction of airway hyperreactivity. The Journal of Immunology 204, 60.65-60.65 (2020).
  • Hurrell, B.P. et al. Distinct roles of LFA-1 and ICAM-1 on ILC2s control lung infiltration, effector functions, and development of airway hyperreactivity. Frontiers in immunology 11, 542818 (2020).
  • Liu, J. et al. Perinatal nicotine exposure‐induced transgenerational asthma: Effects of reexposure in F1 gestation. The FASEB Journal 34, 11444-11459 (2020).
  • Martin, M. Et Al. Evidence For Pulmonary Group 2 Innate Lymphoid Type Ii Cell Involvement In Perinatal Nicotine-Induced Asthma. Journal Of Investigative Medicine 2020. P. A56-A56.
  • Painter, J.D., Galle-Treger, L. & Akbari, O. Role of autophagy in lung inflammation. Frontiers in Immunology11, 1337 (2020).
  • Sattler, F.R. et al. Feasibility of quantifying change in immune white cells in abdominal adipose tissue in response to an immune modulator in clinical obesity. Plos one 15, e0237496 (2020).
  • Shafiei-Jahani, P. et al. DR3 stimulation of adipose resident ILC2s ameliorates type 2 diabetes mellitus. Nature communications 11, 4718 (2020).

2019

  • Galle, L. et al. Costimulation of type-2 innate lymphoid cells by GITR promotes effector function and ameliorates type 2 diabetes. The Journal of Immunology 202, 122.110-122.110 (2019).
  • Galle-Treger, L. et al. Autophagy is critical for type 2 innate lymphoid cell metabolic homeostasis and effector function. European Journal Of Immunology 2019: Wiley. P. 428-429.
  • Galle-Treger, L. et al. Costimulation of type-2 innate lymphoid cells by GITR promotes effector function and ameliorates type 2 diabetes. Nature communications 10, 713 (2019).
  • Han, Y. et al. Large-scale genetic analysis identifies 66 novel loci for asthma. bioRxiv, 749598 (2019).
  • Hirose, S. et al. Roles of type 1, 2, and 3 innate lymphoid cells in herpes simplex virus 1 infection in vitro and in vivo. Journal of Virology 93, 10.1128/jvi. 00523-00519 (2019).
  • Hurrell, B.P. et al. Modulation of ILC2 trafficking and effector functions in ILC2-driven airway hyperreactivity. The Journal of Immunology 202, 51.12-51.12 (2019).
  • Hurrell, B.P. et al. TNFR2 signaling enhances ILC2 survival, function, and induction of airway hyperreactivity. Cell reports 29, 4509-4524. e4505 (2019).
  • Kim, M.H., Akbari, O., Genyk, Y., Kohli, R. & Emamaullee, J. Immunologic benefit of maternal donors in pediatric living donor liver transplantation. Pediatric transplantation 23, e13560 (2019).
  • Lewis, G. et al. Dietary fiber-induced microbial short chain fatty acids suppress ILC2-dependent airway inflammation. Frontiers in immunology 10, 2051 (2019).
  • Li, S. et al. Transcriptional regulation of autophagy-lysosomal function in BRAF-driven melanoma progression and chemoresistance. Nature communications 10, 1693 (2019).
  • Maazi, H. et al. A GWAS approach identifies Dapp1 as a determinant of air pollution-induced airway hyperreactivity. PLoS Genetics 15, e1008528 (2019).
  • Quach, C. et al. A truncating mutation in the autophagy gene UVRAG drives inflammation and tumorigenesis in mice. Nature Communications 10, 5681 (2019).
  • Woodward, N.C. et al. Exposure to nanoscale particulate matter from gestation to adulthood impairs metabolic homeostasis in mice. Scientific reports 9, 1816 (2019).

2018

  • Biefer, H.R.C. et al. Mast cells regulate CD4+ T-cell differentiation in the absence of antigen presentation. Journal of Allergy and Clinical Immunology 142, 1894-1908. e1897 (2018).
  • Hurrell, B.P., Shafiei Jahani, P. & Akbari, O. Social networking of group two innate lymphoid cells in allergy and asthma. Frontiers in immunology 9, 2694 (2018).
  • Maazi, H. et al. Activated plasmacytoid dendritic cells regulate type 2 innate lymphoid cell–mediated airway hyperreactivity. Journal of Allergy and Clinical Immunology 141, 893-905. e896 (2018).
  • Ogasawara, N. et al. IL-10, TGF-β, and glucocorticoid prevent the production of type 2 cytokines in human group 2 innate lymphoid cells. Journal of Allergy and Clinical Immunology 141, 1147-1151. e1148 (2018).
  • Rao, P. et al. Herpes simplex virus 1 specifically targets human CD1d antigen presentation to enhance its pathogenicity. Journal of virology 92, 10.1128/jvi. 01490-01418 (2018).

2017

  • Akbari, O. Maazi H., Suzuki Y., Jung J. Journal Of Allergy And Clinical Immunology 139, 712-713 (2017).
  • Aron, J. & Akbari, O. Regulatory T cells and type 2 innate lymphoid cell‐dependent asthma. Allergy 72, 1148-1155 (2017).
  • Bensman, T.J. et al. Efficacy of rhesus theta-defensin-1 in experimental models of Pseudomonas aeruginosa lung infection and inflammation. Antimicrobial Agents and Chemotherapy 61, 10.1128/aac. 00154-00117 (2017).
  • Maazi, H. & Akbari, O. Type two innate lymphoid cells: the Janus cells in health and disease. Immunological reviews 278, 192-206 (2017).
  • Maazi, H. et al. Toll-like receptor-7-mediated activation of pDCs suppresses the ILC2-mediated airway hyperreactivity and inflammation through type-I interferon. The Journal of Immunology 198, 53.57-53.57 (2017).
  • Maazi, H. et al. Identification of the genetic determinants for the frequency of regulatory T cells using system genetics. The Journal of Immunology 198, 220.210-220.210 (2017).
  • Maazi, H., Suzuki, Y., Jung, J. & Akbari, O. A possible differential role of autophagy in asthma? Journal Of Allergy And Clinical Immunology 139, 712-713 (2017).
  • Poposki, J.A. et al. Group 2 innate lymphoid cells are elevated and activated in chronic rhinosinusitis with nasal polyps. Immunity, inflammation and disease 5, 233-243 (2017).
  • Qin, X. et al. Increased innate lymphoid cells in periodontal tissue of the murine model of periodontitis: the role of AMP-activated protein kinase and relevance for the human condition. Frontiers in immunology 8, 922 (2017).
  • Rigas, D. et al. Type 2 innate lymphoid cell suppression by regulatory T cells attenuates airway hyperreactivity and requires inducible T-cell costimulator–inducible T-cell costimulator ligand interaction. Journal of Allergy and Clinical Immunology 139, 1468-1477. e1462 (2017).

2016

  • Galle-Treger, L. et al. Nicotinic acetylcholine receptor agonist attenuates ILC2-dependent airway hyperreactivity. Nature communications 7, 13202 (2016).
  • Gyllenhammer, L.E. et al. Lower omental t‐regulatory cell count is associated with higher fasting glucose and lower β‐cell function in adults with obesity. Obesity 24, 1274-1282 (2016).
  • Kerzerho, J. et al. Impact of hepatitis C virus on the circulating levels of IL-7 in HIV-1 coinfected women. JAIDS Journal of Acquired Immune Deficiency Syndromes 71, 172-180 (2016).
  • Maazi, H. et al. Impairment of Autophagy in Pulmonary CD11c+ Cells Induces Corticosteroid-Unresponsive Airway Hyperreactivity. Journal of Allergy and Clinical Immunology 137, AB410 (2016).
  • Pulido, M.A. et al. Isoaspartylation appears to trigger small cell lung cancer-associated autoimmunity against neuronal protein ELAVL4. Journal of neuroimmunology 299, 70-78 (2016).
  • Rigas, D. et al. ILC2 suppression by regulatory T cells attenuates airway hyperreactivity and requires ICOS: ICOS-ligand interaction. The Journal of allergy and clinical immunology 139, 1468 (2016).
  • Simmerman, E. et al. Innate lymphoid cells: a paradigm for low SSI in cleft lip repair. Journal of Surgical Research 205, 312-317 (2016).
  • Suzuki, Y. et al. Lack of autophagy induces steroid-resistant airway inflammation. Journal of Allergy and Clinical Immunology 137, 1382-1389. e1389 (2016).
  • Tian, Y., Kuo, C.-f., Akbari, O. & Ou, J.-h.J. Maternal-derived hepatitis B virus e antigen alters macrophage function in offspring to drive viral persistence after vertical transmission. Immunity 44, 1204-1214 (2016).
  • Zhang, J. et al. IκB kinase ε is an NFATc1 kinase that inhibits T cell immune response. Cell reports 16, 405-418 (2016).

2015

  • Maazi, H. & Akbari, O. ICOS regulates ILC2s in asthma. Oncotarget 6, 24584 (2015).
  • Maazi, H. et al. ICOS: ICOS-ligand interaction is essential for ILC2 function and survival (HYP2P. 322). The Journal of Immunology 194, 53.53-53.53 (2015).
  • Maazi, H. et al. ICOS: ICOS-ligand interaction is required for type 2 innate lymphoid cell function, homeostasis, and induction of airway hyperreactivity. Immunity 42, 538-551 (2015).
  • Mott, K.R. et al. Batf3 deficiency is not critical for the generation of CD8α+ dendritic cells. Immunobiology 220, 518-524 (2015).
  • Suzuki, Y. Et Al. Nicotinic Acetylcholine Receptor Agonist Attenuates Innate Lymphocyte Cells Type 2 Dependant Airway Hyper-Reactivity. American Thoracic Society, 2015, Pp A5170-A5170.
  • Suzuki, Y. Et Al. C101 Allergic Airway Inflammation And Hyperresponsiveness: Novel Mechanisms And Therapy. American Journal Of Respiratory And Critical Care Medicine 191, 1 (2015).
  • Wen, X. et al. A subset of CD8αβ+ invariant NKT cells in a humanized mouse model. The Journal of Immunology195, 1459-1469 (2015).

2014

  • Gyllenhammer, L.E. Et Al. T-Regulatory Cells In Omental And Not Subcutaneous Adipose Tissue Inversely Associated With Fasting Glucose In Obese Adults. Diabetes 2014. P. A75-A75.
  • Kerzerho, J., Szely, N., Lombardi, V., Speak, A. & Akbari, O. Nicotine Exposure Abrogates Respiratory Tolerance By Modulating Tolerogenic Dendritic Cells And Regulatory T Cells. Respirology 2014. P. 18-18.
  • Maazi, H., Lombardi, V. & Akbari, O. Response to “CD8 subunit expression by plasmacytoid dendritic cells is variable, and does not define stable subsets”. Mucosal Immunology 7, 1278-1279 (2014).
  • Mott, K.R. et al. Inclusion of CD80 in HSV targets the recombinant virus to PD-L1 on DCs and allows productive infection and robust immune responses. PloS one 9, e87617 (2014).
  • Mott, K.R. et al. Batf3 deficiency is not critical for the generation of CD8+ dendritic cells. (2014).
  • Pulido, M.A. et al. Fluctuating antibody response and CD4-positive T-cells in a small-cell lung cancer mouse model. Cancer Research 74, 3623-3623 (2014).
  • Suzuki, Y., Maazi, H., Lam, J., Jung, J. & Akbari, O. Lack Of Autopgagy In Dendritic Cells Induces Steroid Resistant, Il-17 Dependent Airway Hyperreactivity. American Journal Of Respiratory And Critical Care Medicine189, 1 (2014).
  • Suzuki, Y., Mazzi, H., Lam, J., Jung, J.U. & Akbari, O. Lack Of Autopgagy In Dendritic Cells Induces Steroid Resistant, Il-17 Dependent Airway Hyperreactivity. American Thoracic Society, 2014, Pp A5356-A5356.

2013

  • Akbari, O. et al. Programmed cell death ligand 2 regulates Th9 differentiation and induction of chronic airway hyperreactivity (P6261). The Journal of Immunology 190, 181.113-181.113 (2013).
  • Kerzerho, J. et al. Programmed cell death ligand 2 regulates TH9 differentiation and induction of chronic airway hyperreactivity. Journal of allergy and clinical immunology 131, 1048-1057. e1042 (2013).
  • Liu, J. Et Al. Gender-Specific Effects Of Perinatal Nicotine-Induced Asthma On Upper Vs Lower Airway Of Rat Offspring. Journal Of Investigative Medicine 2013. P. 145-145.
  • Liu, J. et al. Sex-specific perinatal nicotine-induced asthma in rat offspring. American journal of respiratory cell and molecular biology 48, 53-62 (2013).
  • Maazi, H., Lam, J., Lombardi, V. & Akbari, O. Role of plasmacytoid dendritic cell subsets in allergic asthma. Allergy 68, 695-701 (2013).
  • Maazi, H. et al. Lack of PD-L1 expression by iNKT cells improves the course of influenza A infection. PloS one 8, e59599 (2013).
  • Rofoogaran, M., Barbers, R. & Akbari, O. Role Of Il-25 Receptor On Inkt Cells In Human Severe Asthma. American Thoracic Society, 2013, Pp A1256-A1256.

2012

  • Akbari, O. Hadi Maazi, DVM, PhD Yuzo Suzuki, MD, PhD Jae Jung, PhD. Clin Immunol 129, 569-571 (2012).
  • Kerzerho, J. et al. Effects of systemic versus local administration of corticosteroids on mucosal tolerance. The Journal of Immunology 188, 470-476 (2012).
  • Kerzerho, J. et al. Structural and functional characterization of a novel nonglycosidic type I NKT agonist with immunomodulatory properties. Journal of Immunology 189, 4194 (2012).
  • Kerzerho, J. et al. Structural and functional characterization of a novel nonglycosidic type I NKT agonist with immunomodulatory properties. The Journal of Immunology 188, 2254-2265 (2012).
  • Lombardi, V., Speak, A.O., Kerzerho, J., Szely, N. & Akbari, O. CD8α+ β− and CD8α+ β+ plasmacytoid dendritic cells induce Foxp3+ regulatory T cells and prevent the induction of airway hyper-reactivity. Mucosal immunology 5, 432-443 (2012).
  • Rehan, V.K. et al. Perinatal nicotine exposure induces asthma in second generation offspring. BMC medicine 10, 129 (2012).
  • Tian, J. Et Al. Gender-Specific Perinatal Nicotine-Induced Asthma In Rat Offspring. Journal Of Investigative Medicine 2012. P. 158-158.

2011

  • Babu, J., Lombardi, V., Akbari, O. & Barbers, R. Expression of IL-25 Receptors on iNKT Cells From Patients With Severe Asthma. Chest 140, 228A (2011).
  • Li, M. et al. Epithelium-specific deletion of TGF-β receptor type II protects mice from bleomycin-induced pulmonary fibrosis. The Journal of clinical investigation 121, 277-287 (2011).
  • Lombardi, V., Szely, N. & Akbari, O. Co-expression of CD8α and CD8β defines a subset of tolerogenic plasmacytoid dendritic cells able to induce the differentiation of Foxp3+ regulatory T cells. The Journal of Immunology 186, 103.109-103.109 (2011).
  • Singh, A.K., Stock, P. & Akbari, O. Role of PD‐L1 and PD‐L2 in allergic diseases and asthma. Allergy 66, 155-162 (2011).

2010

  • Akbari, O. et al. PD-L1 and PD-L2 modulate airway inflammation and iNKT-cell-dependent airway hyperreactivity in opposing directions. Mucosal immunology 3, 81-91 (2010).
  • Albacker, L.A. et al. TIM-4, a receptor for phosphatidylserine, controls adaptive immunity by regulating the removal of antigen-specific T cells. The Journal of Immunology 185, 6839-6849 (2010).
  • Lombardi, V., Singh, A.K. & Akbari, O. The role of costimulatory molecules in allergic disease and asthma. International archives of allergy and immunology 151, 179-189 (2010).
  • Lombardi, V. et al. A CD1d-dependent antagonist inhibits the activation of invariant NKT cells and prevents development of allergen-induced airway hyperreactivity. The journal of immunology 184, 2107-2115 (2010).

2009

  • Akbari, O., Stock, P., Lombardi, V. Induction of Airway Hyperreactivity by IL-25. J Immunol182, 5116-5122 (2009).
  • Albacker, L. et al. TIM-4 Negatively Regulates Immune Responses by Reducing Antigen Specific T Cell Numbers. Clinical Immunology 131, S36-S36 (2009).
  • Lombardi, V. & Akbari, O. Dendritic cell modulation as a new interventional approach for the treatment of asthma. Drug news & perspectives 22, 445 (2009).
  • Matangkasombut, P. et al. Natural killer T cells in the lungs of patients with asthma. Journal of allergy and clinical immunology 123, 1181-1185. e1181 (2009).
  • Stock, P., Lombardi, V., Kohlrautz, V. & Akbari, O. Induction of airway hyperreactivity by IL-25 is dependent on a subset of invariant NKT cells expressing IL-17RB. The Journal of Immunology 182, 5116-5122 (2009).

2008

  • Akbari, O. et al. ICOS/ICOSL interaction is required for CD4+ invariant NKT cell function and homeostatic survival. The Journal of Immunology 180, 5448-5456 (2008).
  • Exley, M.A. et al. Selective activation, expansion, and monitoring of human iNKT cells with a monoclonal antibody specific for the TCR α‐chain CDR3 loop. European journal of immunology 38, 1756-1766 (2008).
  • Koh, Y.I. et al. Activation of nonclassical CD1d-restricted NK T cells induces airway hyperreactivity in β2-microglobulin-deficient mice. The Journal of Immunology 181, 4560-4569 (2008).
  • Stock, P. & Akbari, O. Recent advances in the role of NKT cells in allergic diseases and asthma. Current Allergy and Asthma Reports 8, 165-170 (2008).

2007

  • Akbari, O. PS2-2 The role of iNKT cells in development and pathogenesis of allergic disease and asthma. Japanese Journal of Allergology 56, 939 (2007).
  • Akbari, O., Faul, J.L. & Umetsu, D.T. Invariant natural killer T cells in obstructive pulmonary diseases. The New England journal of medicine 357, 193-194 (2007).
  • Akbari, O. et al. ICOS/ICOSL interaction is required for CD4+ NKT cells function and for the induction of airway hyperreactivity (39.4). The Journal of Immunology 178, S25-S25 (2007).
  • Akbari, O., Yang, W., Meyer, E., Umetsu, D.T. & Wilson, S.B. A CD1d-dependent antagonist inhibits the activation of iNKT cells and prevents development of allergen-induced airway hyperreactivity (39.9). The Journal of Immunology 178, S27-S27 (2007).
  • Stock, P. et al. Induction of T (H) 1-like regulatory cells that express Foxp3 and protect against airway hyperreactivity. European Journal Of Pediatrics 2007: Springer. P. 287-288.

2006

  • Akbari, O. The role of iNKT cells in development of bronchial asthma: a translational approach from animal models to human. Allergy 61, 962-968 (2006).
  • Akbari, O. et al. CD4+ invariant T-cell–receptor+ natural killer T cells in bronchial asthma. New England Journal of Medicine 354, 1117-1129 (2006).
  • Akbari, O., Faul, J.L. & Umetsu, D.T. Invariant Natural Killer T Cells in Bronchial Asthma. New England Journal of Medicine 354, 2615-2616 (2006).
  • Akbari, O. & Umetsu, D.T. Reply to Natural killer T cells and CD8+ T cells are dispensable for T cell–dependent allergic airway inflammation. Nature Medicine 12, 1347-1347 (2006).
  • Akbari, O. & Umetsu, D.T. Natural killer T cells and CD8+ T cells are dispensable for T cell-dependent allergic airway inflammation. Nature medicine 12, 1345-1347 (2006).
  • Meyer, E.H. et al. Glycolipid activation of invariant T cell receptor+ NK T cells is sufficient to induce airway hyperreactivity independent of conventional CD4+ T cells. Proceedings of the National Academy of Sciences 103, 2782-2787 (2006).

2005

  • Akbari, O. et al. CD4 (+) invariant T cell receptor (+) NKT cells and the development of bronchial asthma in humans. Clinical Immunology 2005. P. S16-S17.
  • Akbari, O. & Umetsu, D.T. Role of regulatory dendritic cells in allergy and asthma. Current allergy and asthma reports 5, 56-61 (2005).
  • Meyer, E. et al. Glycolipid mediated activation of iNKT cells is sufficient to induce airway hyperreactivity independent of conventional CD4 T cells. Clinical Immunology 2005. P. S14-S15.
  • Stock, P., Akbari, O., DeKruyff, R.H. & Umetsu, D.T. Respiratory tolerance is inhibited by the administration of corticosteroids. The Journal of Immunology 175, 7380-7387 (2005).
  • Stock, P., Akbari, O., Freeman, G., DeKruyff, R. & Umetsu, D. Induction of THI-like regulatory cells that express Foxp3 and protect against airway hyperreactivity. Clinical Immunology 2005. P. S11-S11.
  • Umetsu, D.T. et al. NKT cells regulate the development of asthma. International Congress Series 2005: Elsevier. p. 184-188.
  • Umetsu, S. et al. Costimulation by TIM-1 induces T cell activation and inhibits the development of peripheral tolerance. Faseb Journal 2005. P. A905-A905.
  • Umetsu, S.E. et al. TIM-1 induces T cell activation and inhibits the development of peripheral tolerance. Nature immunology 6, 447-454 (2005).

2004

  • Akbari, O. & Umetsu, D.T. Role of regulatory dendritic cells in allergy and asthma. Current Opinion in Allergy and Clinical Immunology 4, 533-538 (2004).
  • Stock, P. et al. Induction of T helper type 1–like regulatory cells that express Foxp3 and protect against airway hyper-reactivity. Nature immunology 5, 1149-1156 (2004).
  • Stock, P. et al. CD8+ T cells regulate immune responses in a murine model of allergen‐induced sensitization and airway inflammation. European journal of immunology 34, 1817-1827 (2004).

2003

  • Akbari, O., Freeman, G. & Meyer, E. Primary immune deficiency. Cardiovasc Res 59, 95-104 (2003).
  • Akbari, O., Stock, P., DeKruyff, R.H. & Umetsu, D.T. Role of regulatory T cells in allergy and asthma. Current opinion in immunology 15, 627-633 (2003).
  • Akbari, O., Stock, P., DeKruyff, R.H. & Umetsu, D.T. Mucosal tolerance and immunity: regulating the development of allergic disease and asthma. International archives of allergy and immunology 130, 108-118 (2003).
  • Akbari, O. et al. Essential role of NKT cells producing IL-4 and IL-13 in the development of allergen-induced airway hyperreactivity. Nature medicine 9, 582-588 (2003).
  • Umetsu, D.T., Akbari, O. & DeKruyff, R.H. Regulatory T cells control the development of allergic disease and asthma. Journal of Allergy and Clinical Immunology 112, 480-487 (2003).
  • Umetsu, D.T. et al. Regulatory T cells control the development of allergic disease and asthma. Journal of Allergy and Clinical Immunology 112, 480-487 (2003).

2002

  • Akbari, O. et al. Antigen-specific regulatory T cells develop via the ICOS–ICOS-ligand pathway and inhibit allergen-induced airway hyperreactivity. Nature medicine 8, 1024-1032 (2002).
  • Oh, J.-W. et al. CD4 T-helper cells engineered to produce IL-10 prevent allergen-induced airway hyperreactivity and inflammation. Journal of allergy and clinical immunology 110, 460-468 (2002).
  • Umetsu, D. et al. Nature Review. Nature Immunology (2002).
  • Umetsu, D.T., McIntire, J.J., Akbari, O., Macaubas, C. & DeKruyff, R.H. Asthma: an epidemic of dysregulated immunity. Nature immunology 3, 715-720 (2002).

2001

  • Akbari, O., DeKruyff, R.H. & Umetsu, D.T. Pulmonary dendritic cells producing IL-10 mediate tolerance induced by respiratory exposure to antigen. Nature immunology 2, 725-731 (2001).
  • McIntire, J.J. et al. Identification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene family. Nature immunology 2, 1109-1116 (2001).

1999

  • Akbari, O. Analysis of the basis for induction and maintenance of T cell responses in DNA vaccination. University College London, 1999.
  • Akbari, O. et al. DNA vaccination: transfection and activation of dendritic cells as key events for immunity. The Journal of experimental medicine 189, 169-178 (1999).
  • Panjwani, N., Akbari, O., Garcia, S., Brazil, M. & Stockinger, B. The HSC73 molecular chaperone: involvement in MHC class II antigen presentation. The Journal of Immunology 163, 1936-1942 (1999).
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