Liang et al. Zika Virus NS4A-NS4B inhibition of Akt-mTOR pathway contributes to neurogenesis defect and autophagy induction of human fetal neural stem cells. 2016 Cell Stem Cell. In Press.
Lee et al. Transformation of glutamyl-prolyl tRNA synthetase into an antiviral molecule via infection-specific modification. 2016 Nature Immunology. In press
Lee et al. TPL2 Is an oncogenic driver in keratocanthoma and squamous cell carcinoma. 2016 Cancer Res. In press.
Toth et al. LANA-mediated recruitment of host Polycomb Repressive Complexes onto the KSHV genome during de novo infection. 2016 PLoS Pathogen. 12(9):e1005878.
Seo et al. No Trifling matter on STING. 2016 Cell Host & Microbe. 20(3):277-8
Zhu et al. An oncogenic virus promotes cell survival and cellular transformation by suppressing glycolysis. 2016 PLoS Pathogens. 12(5):e1005648.
Choi et al. HDAC6 regulates the cellular viral RNA sensing by deacetylation of RIG-I. EMBO J. 2016 Feb 15;35(4):429-42.
Seo et al. AKT-mediated checkpoint of cGAS DNA sensing pathway. 2015 Cell Report. 13(2):440-9.
Yoo et al. The mitochondrial E3 ubiquitin ligase MARCH5 negatively regulates the MAVS-mediated innate immune response. 2015 Nature Communication. 6:7910.
Zhang Jet al. Herpesviral G protein-coupled receptors activate NFAT to induce tumor formation via inhibiting the SERCA calcium ATPase. 2015 PLoS Pathogen. 11(3):e1004768.
Chen et al. Harnessing negative B cell selection to overcome drug-resistance in Ph+ acute lymphoblastic leukemia. 2015 Nature. 521:357-361
He et al. Herpesviral Pseudo-enzymes Induce RIG-I Deamination and Ligand-independent Activation. 2015 Mol Cell. 58:134-146.
Liang et al. Novel functions of viral anti-apoptotic factors. 2015 Nat Rev Microbiol. 13:7-12.
Lee et al. Exploitation of Complement System by Oncogenic Kaposi’s Sarcoma-Associated Herpesvirus for Cell Survival and Persistent Infection. 2014 PLoS Pathogens. 10:e1004412
Shi et al. Negative regulation of NF-B activity by brain-specific TRIpartite Motif protein 9. 2014 Nature Communication. 5:4820./
Fan et al. USP21 negatively regulates antiviral response by acting as a RIG-I deubiquitinase. 2014 Journal of Experimental Medicine. 211:313-28.
Rodgers et al. Ubiquitination-mediated activation of NLRP3-inflammasome activity. 2014 Journal of Experimental Medicine. 211:1333-47.
Full et al. Kaposi’s sarcoma associated herpesvirus tegument protein ORF75 is essential for viral lytic replication and plays a critical role in the antagonization of ND10-instituted intrinsic immunity. 2014 PLoS Pathogen. 10:e1003863.
Liang Q et al. cGAS and Beclin-1 interaction shapes innate immune responses by regulating cGAMP production and autophagy pathway. 2014 Cell Host & Microbe. 15: 228-238.
Toth Z et al. Biphasic euchromatin-to-heterochromatin transition on the KSHV genome following de novo infection. 2013 PLoS Pathogen. 9(12):e1003813.
Amini-Bavil-Olyaee S, et al. A novel mechanism of IFITM-mediated anti-viral activity. 2013 Cell Host Microbe. 13:452-464.
Yang CS et al. Rubicon autophagic protein is a feedback inhibitor of CARD9-mediated host innate immunity. 2012 Cell Host & Microbe. 11:277-289.
Yang CS et al. Rubicon autophagic protein is a positive regulator of the reactive oxygen species generating NADPH oxidase complex. 2012 Cell Host & Microbe. 11:262-276.
Lee HR et al. Viral peptide inhibitors of HAUSP to induce apoptosis. 2011 Nature Structural & Molecular Biology. 18:1336-1344.
Inn KS et al. Linear Ubiquitin Assembly Complex Negatively Regulates RIG-I- and TRIM25-Mediated Type I Interferon Induction. 2011 Mol Cell. 41:354-65.
Toth et al. Epigenetic regulation of latency and reactivation of Kaposi’s sarcoma-associated herpesvirus. 2010 PLoS Pathogen. 6(7):e10013
Chang et al. Nonhuman primate model for KSHV persistent infection. 2009 PLoS Pathogen. 5(10):e1000606.
E X et al. Viral Bcl-2- mediated evasion of autophagy aids chronic infection of gherpesvirus 68. 2009 PLoS Pathogen. 5(10):e1000609.
Gack et al. Inhibition of TRIM25-mediated RIG-I anti-viral activity by Influenza A virus. 2009 Cell Host & Microbes. 5(5):439-49.
Myong et al. Cytosolic viral sensor RIG-I is a 5’-triphosphate dependent translocase on double stranded RNA. 2009 Science. 323:1070-1074.
Lee et al. FLIP-mediated cell death control. 2009 Nature Cell Biology. 11:1355-62
Min CK et al. The role of membrane-proximal amphipathic helix of Tip in membrane deformation and TCR downregulation. 2008 PLoS Pathogen. 4(11):e1000209.
Ku et al. Structural and biochemical bases for the inhibition of autophagy and apoptosis by viral BCL-2 of murine gamma-herpesvirus 68. PLOS Pathogen. 2008 4(2):e25
Gack et al. Roles of RIG-I N-terminal tandem CARD and splice variant in TRIM25-mediated antiviral signal transduction Proc Natl Acad Sci U S A. 2008 105(43): 16743-16748.
Liang et al. Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking. Nature Cell Biology. 2008 Jul;10(7):776-87
Feng et al. A novel inhibitory mechanism of mitochondrion-dependent apoptosis by a herpesviral protein. PLoS Pathog. 2007 Dec;3(12):e174.
Takahashi et al. Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis. Nat Cell Biol. 2007 Oct;9(10):1142-51.
Gack et al. TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity. Nature. 2007 Apr 19;446(7138):916-920.
Liang et al. Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG. Nat Cell Biol. 2006 Jul;8(7):688-99.
Cho et al. Inhibition of T cell receptor signal transduction by tyrosine kinase-interacting protein of Herpesvirus saimiri. J Exp Med. 2004 Sep 6;200(5):681-7.
Park et al. Herpesviral protein targets a cellular WD repeat endosomal protein to downregulate T lymphocyte receptor expression. Immunity. 2002 Aug;17(2):221-33.
Means et al. Multiple endocytic trafficking pathways of MHC class I molecules induced by a Herpesvirus protein. EMBO J. 2002 Apr 2;21(7):1638-49.
Ishido et al. Inhibition of natural killer cell-mediated cytotoxicity by Kaposi’s sarcoma-associated herpesvirus K5 protein. Immunity. 2000 Sep;13(3):365-74.
Lee et al. Inhibition of intracellular transport of B cell antigen receptor complexes by Kaposi’s sarcoma-associated herpesvirus K1. J Exp Med. 2000 Jul 3;192(1):11-21.
Lee et al. Deregulation of cell growth by the K1 gene of KSHV. 1998. Nature Medicine. 4:435-440.
Yoon et al. Tap; a novel cellular protein that interacts with tip of herpesvirus saimiri and induces lymphocyte aggregation. Immunity. 1997; 6:571-582.
Duboise et al. Use of virion DNA as a cloning vector for the construction of mutant and recombinant herpesviruses. Proc. Natl. Acad. Sci.. 1996; 93:11389-11394.
Du et al. Identification of a nef allele that causes lymphocyte activation and acute disease in macaque monkeys. Cell. 1995; 82:665-674
Jung et al. Identification of transforming genes of subgroup A and C strains of Herpesvirus saimiri. Proc. Natl. Acad. Sci. USA. 1991; 88:7051-7055