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My research interest involves two things: Viral protein structure and Immunotherapy. I am currently focusing on identifying a viral GPCR structure to get an insight how it triggers the oncogenic switch when it invades human cells. At the same time, I am trying to come up with a fusion CAR (Chimeric Antigen Receptor) that may improve the current CAR-T immunotherapy strategy.
My research focuses on host-pathogen interactions. Currently, I am working on Heartland virus (HRTV), a tick-borne pathogen in the United States. I want to find new mechanisms by which the virus could invade the host and induce the host’s innate immune response.
The immune system protects the host against viral pathogens. In response, many viruses have developed strategies to avoid detection and elimination by the host immune system. One of these immune evasion mechanisms is the inhibition of host cell death. Necroptosis is an important innate immune defense mechanism against certain viruses. I am interested in how host cell death during pathogen infections can alter the course of the host immune response. On the other hand, I am also interested in exploring the mechanisms employed by different viral pathogens in combating the host cell death machinery.
My research interests are directed on osteoimmunology of mosquito-borne viruses including chikungunya virus (CHIKV) and Zika virus (ZIKV). Specifically, I am interested in studying how the regulation of host immune responses modulates the bone remodeling system during viral-induced inflammatory diseases.
My research interest revolves around deciphering the role of innate immunity in triggering the pathogenesis associated with mosquito-borne viruses such as Chikungunya virus (CHIKV) and Zika virus (ZIKV). In particular, I am interested in studying how the heterogeneity of monocytes and macrophages serves as a double-edged sword in modulating the disease outcomes.
My research interests are focused on antiviral therapeutics, including antivirals and vaccines. Currently, I am working on discovering functional receptor for SFTS (Severe Fever with Thrombocytopenia Syndrome) virus, a newly identified Bunyavirus, for the discovery of novel antivirals targeting SFTS virus entry. Moreover, I am studying the stabilization of inactivated polio vaccine (IPV). By improving the stability of IPV, it will improve vaccine distribution in developing countries without the need of a cold-chain transport.
I’m interested in developing animal model and in vitro 3D model system to identify novel and crucial oncogenic process by KSHV that is not detected in traditional in vitro culture system. To achieve this goal, I’m performing basic and translational researches : (1) Utilizing humanized mouse model for KSHV pathogenesis, (2) Identification novel role of KSHV K1 regulate host proline metabolism, (3) developing 3D culture system for investigating unidentified functions of viral oncogene.
I am interested in the regulation of innate immune response. Specifically, I am studying the role of epigenetic regulation on innate immunity. Moreover, I am studying a newly identified Bunyavirus, SFTSV (severe fever with thrombocytopenia syndrome virus) to understand its infection and immune evasion mechanisms.
My interest is directed at understanding of host recognition and viral evasion upon viral infection, specifically during delivery of the viral genome to the host cell. Using RNAi and yeast genetics, I will explore novel protein interactions involved in viral DNA sensing and viral evasion immediately following infection and during viral genome replication.
The goal of my research is to explore the respective roles of caspases in innate immunity. Inflammatory caspases are key enzymes executing cytokine production and pyroptosis. Currently, I am studying the regulatory mechanisms of these enzymes during viral and bacterial infections.