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I am interested in the identification of key viral and host factors involved in viral entry and carcinogenesis by combining molecular virology, biochemistry, cell biology and chemical biology on many important viruses such as EBV, ZIKV, CHIKV, SFTSV, HPV and so on. In addition, I am also interested in the establishment and optimization of viral infection system as well as the development of novel antiviral interventions towards a cure for infection.
My research interests are directed on osteoimmunology of mosquito-borne viruses including chikungunya virus (CHIKV) and Zika virus (ZIKV). Specifically, I am interested in studying how the regulation of host immune responses modulates the bone remodeling system during viral-induced inflammatory diseases.
My research interest revolves around deciphering the role of innate immunity in triggering the pathogenesis associated with mosquito-borne viruses such as Chikungunya virus (CHIKV) and Zika virus (ZIKV). In particular, I am interested in studying how the heterogeneity of monocytes and macrophages serves as a double-edged sword in modulating the disease outcomes.
My research interests are focused on antiviral therapeutics, including antivirals and vaccines. Currently, I am working on discovering functional receptor for SFTS (Severe Fever with Thrombocytopenia Syndrome) virus, a newly identified Bunyavirus, for the discovery of novel antivirals targeting SFTS virus entry. Moreover, I am studying the stabilization of inactivated polio vaccine (IPV). By improving the stability of IPV, it will improve vaccine distribution in developing countries without the need of a cold-chain transport.
I’m interested in developing animal model and in vitro 3D model system to identify novel and crucial oncogenic process by KSHV that is not detected in traditional in vitro culture system. To achieve this goal, I’m performing basic and translational researches : (1) Utilizing humanized mouse model for KSHV pathogenesis, (2) Identification novel role of KSHV K1 regulate host proline metabolism, (3) developing 3D culture system for investigating unidentified functions of viral oncogene.
My research aims to uncover the molecular mechanisms underlying host defense against DNA virus infection. I am interested in the upstream initiating protein complex and signaling that engage expression of anti-viral cytokines during innate immune response.
I am interested in the regulation of innate immune response. Specifically, I am studying the role of epigenetic regulation on innate immunity. Moreover, I am studying a newly identified Bunyavirus, SFTSV (severe fever with thrombocytopenia syndrome virus) to understand its infection and immune evasion mechanisms.
My interest is directed at understanding of host recognition and viral evasion upon viral infection, specifically during delivery of the viral genome to the host cell. Using RNAi and yeast genetics, I will explore novel protein interactions involved in viral DNA sensing and viral evasion immediately following infection and during viral genome replication.
The goal of my research is to explore the respective roles of caspases in innate immunity. Inflammatory caspases are key enzymes executing cytokine production and pyroptosis. Currently, I am studying the regulatory mechanisms of these enzymes during viral and bacterial infections.